SF3A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SF3A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SF3A1
  * **<color #00a2e8>Official Name</color>**: splicing factor 3a subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10291|10291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15459|Q15459]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SF3A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SF3A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605595|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Surp|
|ubiquitin|
|PRP21 like P|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type prespliceosome assembly|
|mRNA 3-splice site recognition|
|U2-type spliceosomal complex|
|U2-type prespliceosome|
|U2 snRNP|
|mRNA splice site selection|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.98|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.93|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.78|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.64|
|[[:results:exp539|42°C R08 exp539]]|-2.35|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.33|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.95|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.87|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.73|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.73|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|1.79|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.8|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.8|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.81|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.89|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.91|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.92|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.95|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.98|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.13|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.22|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.4|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.41|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.53|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.543|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.542|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.535|
|[[:human genes:p:psmb4|PSMB4]]|0.533|
|[[:human genes:t:tceb3c|TCEB3C]]|0.516|
|[[:human genes:c:c14orf93|C14orf93]]|0.514|
|[[:human genes:v:vasn|VASN]]|0.513|
|[[:human genes:o:orc1|ORC1]]|0.507|
|[[:human genes:c:cdc6|CDC6]]|0.507|
|[[:human genes:r:rpl35|RPL35]]|0.504|
|[[:human genes:c:chd4|CHD4]]|0.501|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.499|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.498|
|[[:human genes:a:aamp|AAMP]]|0.498|
|[[:human genes:r:rps2|RPS2]]|0.495|
|[[:human genes:s:supt5h|SUPT5H]]|0.493|
|[[:human genes:p:polr2f|POLR2F]]|0.491|
|[[:human genes:b:bysl|BYSL]]|0.49|
|[[:human genes:i:iscu|ISCU]]|0.483|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.481|
|[[:human genes:n:npipb5|NPIPB5]]|0.481|
|[[:human genes:k:kif3c|KIF3C]]|0.481|
|[[:human genes:c:cope|COPE]]|0.481|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.48|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.479|
|[[:human genes:c:copg1|COPG1]]|0.479|
|[[:human genes:p:pwp2|PWP2]]|0.479|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.479|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.478|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.476|
|[[:human genes:t:ticrr|TICRR]]|0.476|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.475|
|[[:human genes:d:dido1|DIDO1]]|0.475|
|[[:human genes:p:paf1|PAF1]]|0.474|
|[[:human genes:i:igfn1|IGFN1]]|0.473|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.471|
|[[:human genes:r:rbbp5|RBBP5]]|0.47|
|[[:human genes:t:tfip11|TFIP11]]|0.469|
|[[:human genes:p:pola2|POLA2]]|0.467|
|[[:human genes:c:cbwd5|CBWD5]]|0.467|
|[[:human genes:t:tyms|TYMS]]|0.466|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.464|
|[[:human genes:c:cbwd3|CBWD3]]|0.464|
|[[:human genes:a:aqr|AQR]]|0.461|
|[[:human genes:p:polr2j3|POLR2J3]]|0.46|
|[[:human genes:s:sf3a2|SF3A2]]|0.456|
|[[:human genes:p:pan3|PAN3]]|0.455|
|[[:human genes:c:cdc73|CDC73]]|0.455|
|[[:human genes:c:cbwd6|CBWD6]]|0.454|
|[[:human genes:d:ddtl|DDTL]]|0.454|
|[[:human genes:n:nup160|NUP160]]|0.454|
|[[:human genes:c:cwc22|CWC22]]|0.454|
|[[:human genes:n:narfl|NARFL]]|0.454|
|[[:human genes:n:npipb8|NPIPB8]]|0.453|
|[[:human genes:r:rbm39|RBM39]]|0.452|
|[[:human genes:o:orc6|ORC6]]|0.452|
|[[:human genes:w:wdr75|WDR75]]|0.452|
|[[:human genes:c:copb2|COPB2]]|0.452|
|[[:human genes:l:lrr1|LRR1]]|0.451|
|[[:human genes:s:sart1|SART1]]|0.451|
|[[:human genes:r:rad51|RAD51]]|0.451|
|[[:human genes:s:snip1|SNIP1]]|0.45|
|[[:human genes:c:cep192|CEP192]]|0.45|
|[[:human genes:c:copb1|COPB1]]|0.45|
|[[:human genes:b:brd2|BRD2]]|0.448|
|[[:human genes:m:myo1h|MYO1H]]|0.446|
|[[:human genes:p:psmd11|PSMD11]]|0.446|
|[[:human genes:p:psmd1|PSMD1]]|0.446|
|[[:human genes:r:rps5|RPS5]]|0.445|
|[[:human genes:c:copa|COPA]]|0.445|
|[[:human genes:h:hap1|HAP1]]|0.444|
|[[:human genes:m:myb|MYB]]|0.443|
|[[:human genes:c:cactin|CACTIN]]|0.441|
|[[:human genes:p:psmd14|PSMD14]]|0.441|
|[[:human genes:s:snrpa1|SNRPA1]]|0.44|
|[[:human genes:c:ccdc94|CCDC94]]|0.439|
|[[:human genes:z:znf106|ZNF106]]|0.439|
|[[:human genes:p:prkcz|PRKCZ]]|0.438|
|[[:human genes:c:copz1|COPZ1]]|0.437|
|[[:human genes:r:rps9|RPS9]]|0.436|
|[[:human genes:g:golga8o|GOLGA8O]]|0.436|
|[[:human genes:p:psmd3|PSMD3]]|0.436|
|[[:human genes:n:nup62|NUP62]]|0.435|
|[[:human genes:p:pole|POLE]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.433|
|[[:human genes:n:nsf|NSF]]|0.433|
|[[:human genes:a:ankle2|ANKLE2]]|0.432|
|[[:human genes:p:psma6|PSMA6]]|0.432|
|[[:human genes:p:psmb1|PSMB1]]|0.431|
|[[:human genes:r:rps12|RPS12]]|0.43|
|[[:human genes:s:stil|STIL]]|0.429|
|[[:human genes:m:myh2|MYH2]]|0.428|
|[[:human genes:a:akirin2|AKIRIN2]]|0.427|
|[[:human genes:i:ints6|INTS6]]|0.427|
|[[:human genes:c:ckap5|CKAP5]]|0.426|
|[[:human genes:m:mt1e|MT1E]]|0.425|
|[[:human genes:p:pole2|POLE2]]|0.424|
|[[:human genes:d:dtl|DTL]]|0.424|
|[[:human genes:l:lad1|LAD1]]|0.423|
|[[:human genes:c:chaf1a|CHAF1A]]|0.423|
|[[:human genes:a:arhgef15|ARHGEF15]]|0.423|
|[[:human genes:a:aaas|AAAS]]|0.423|
|[[:human genes:g:gga3|GGA3]]|0.423|
|[[:human genes:i:ik|IK]]|0.422|
|[[:human genes:s:sf3b1|SF3B1]]|0.422|
|[[:human genes:s:sec13|SEC13]]|0.422|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.421|
|[[:human genes:r:rnf113a|RNF113A]]|0.421|
|[[:human genes:e:exosc6|EXOSC6]]|0.42|
|[[:human genes:c:cgb2|CGB2]]|0.42|
|[[:human genes:c:casc3|CASC3]]|0.42|
|[[:human genes:r:rpl14|RPL14]]|0.42|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.419|
|[[:human genes:p:plekha4|PLEKHA4]]|0.419|
|[[:human genes:e:eif3g|EIF3G]]|0.419|
|[[:human genes:s:snrnp70|SNRNP70]]|0.419|
|[[:human genes:s:scaf1|SCAF1]]|0.419|
|[[:human genes:h:hinfp|HINFP]]|0.419|
|[[:human genes:n:ncapg|NCAPG]]|0.419|
|[[:human genes:t:terf1|TERF1]]|0.418|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.418|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.418|
|[[:human genes:x:xab2|XAB2]]|0.417|
|[[:human genes:d:disp2|DISP2]]|0.417|
|[[:human genes:r:rps11|RPS11]]|0.417|
|[[:human genes:p:pola1|POLA1]]|0.416|
|[[:human genes:u:uqcrh|UQCRH]]|0.416|
|[[:human genes:n:nup205|NUP205]]|0.416|
|[[:human genes:s:sf3a3|SF3A3]]|0.416|
|[[:human genes:r:rrp7a|RRP7A]]|0.415|
|[[:human genes:n:nup133|NUP133]]|0.415|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.414|
|[[:human genes:k:kctd17|KCTD17]]|0.414|
|[[:human genes:f:fancm|FANCM]]|0.413|
|[[:human genes:g:golga8j|GOLGA8J]]|0.413|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.412|
|[[:human genes:n:nupl1|NUPL1]]|0.411|
|[[:human genes:t:tspy8|TSPY8]]|0.411|
|[[:human genes:p:prpf8|PRPF8]]|0.411|
|[[:human genes:i:ints5|INTS5]]|0.41|
|[[:human genes:p:ppfia4|PPFIA4]]|0.41|
|[[:human genes:m:myt1l|MYT1L]]|0.409|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.408|
|[[:human genes:p:psma7|PSMA7]]|0.407|
|[[:human genes:t:twistnb|TWISTNB]]|0.407|
|[[:human genes:p:psmb2|PSMB2]]|0.407|
|[[:human genes:z:znf655|ZNF655]]|0.407|
|[[:human genes:t:timeless|TIMELESS]]|0.406|
|[[:human genes:t:terf2|TERF2]]|0.406|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.405|
|[[:human genes:t:top1mt|TOP1MT]]|0.405|
|[[:human genes:a:adamtsl4|ADAMTSL4]]|0.404|
|[[:human genes:h:hivep3|HIVEP3]]|0.404|
|[[:human genes:g:gprin2|GPRIN2]]|0.403|
|[[:human genes:p:psmd7|PSMD7]]|0.403|
|[[:human genes:r:rilpl1|RILPL1]]|0.402|
|[[:human genes:s:setd1a|SETD1A]]|0.402|
|[[:human genes:n:nip7|NIP7]]|0.402|
|[[:human genes:t:taf1|TAF1]]|0.401|
|[[:human genes:w:wdr90|WDR90]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 331
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SF3A1 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>