MYT1L

Gene Information

Official Symbol: MYT1L
Official Name: myelin transcription factor 1 like
Aliases and Previous Symbols: N/A
Entrez ID: 23040
UniProt: Q9UL68
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017].
UniProt Summary: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non- neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT- 3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. {ECO:0000250|UniProtKB:P97500}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CFI-400945 25μM R08 exp469	-1.93
Rotenone 20μM R00 exp34	-1.9
Hinokiflavone 12μM R08 exp487	-1.8
5-Azacytidine 2μM R07 exp330	1.7
Resminostat 0.5μM R07 exp393	1.7
Dimethyloxaloylglycine 11μM R07 exp314	1.81
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.82
BRD2 inhibitor II 20μM R07 exp341	1.86
Geldanamycin 0.01μM R05 exp235	1.89
Docosahexaenoic-acid 50μM R07 exp356	1.92
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.97
Tubacin 1.6μM R07 exp416	2.21
FK-506 5μM R07 exp358	2.23

Gene	Correlation
CHD4	0.523
TCEB3CL2	0.498
C14orf93	0.497
RRM1	0.494
TBC1D3F	0.492
DISP2	0.492
RPS2	0.486
TBC1D3H	0.484
CCNA2	0.477
C1QTNF9B	0.475
KIF3C	0.473
NOP16	0.471
VASN	0.466
TBC1D3G	0.465
MYO1H	0.463
NPIPB5	0.463
ORC6	0.462
EXOSC5	0.462
TCEB3C	0.462
SUPT5H	0.46
TCEB3CL	0.458
TRIM52	0.457
AKIRIN2	0.452
HIST1H4B	0.449
TBC1D3	0.449
KCTD17	0.447
DDTL	0.447
SEC13	0.445
POLA1	0.442
DDX51	0.44
TBC1D3L	0.438
TBC1D3E	0.438
TBC1D3I	0.438
TBC1D3K	0.438
ATP1A3	0.438
PAF1	0.437
POLR2F	0.436
CRNKL1	0.436
NAPA	0.435
RAD51	0.433
STIL	0.431
SLC6A17	0.431
CBWD5	0.43
CBWD3	0.428
RPS12	0.428
RBBP5	0.424
COPG1	0.423
SEZ6L2	0.422
HIVEP3	0.421
MADCAM1	0.421
ATXN1	0.42
HIST2H2BF	0.418
PLK4	0.417
FAM25B	0.416
SNRPA1	0.415
HIST2H3C	0.414
ANKLE2	0.413
HIST2H3A	0.413
TBC1D3C	0.413
AAMP	0.413
POLE	0.411
PWP2	0.41
LAD1	0.41
WDR87	0.41
SF3A1	0.409
PDE4DIP	0.409
TRA2B	0.409
EXOSC6	0.409
SMG7	0.406
DTL	0.406
SLC4A1	0.405
SSH2	0.405
PSMD11	0.404
PSMB4	0.403
PSMA6	0.402
CWC22	0.401
CACNA1A	0.401
PSMD1	0.401
MT1E	0.401
MYB	0.4
TTC1	0.4
NUP54	0.4

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2035
Expression level (log2 read counts): 2.49

Expression Distribution

MYT1
zf-C2HC

neuron fate specification
neuron fate commitment
cell fate specification
chromosome
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
neuron development
zinc ion binding
negative regulation of transcription by RNA polymerase II
neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process