MYT1L [The Human Chemical-Genetic Interaction Map Project]

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======= MYT1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYT1L
  * **<color #00a2e8>Official Name</color>**: myelin transcription factor 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23040|23040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL68|Q9UL68]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYT1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYT1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613084|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non- neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT- 3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. {ECO:0000250|UniProtKB:P97500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MYT1|
|zf-C2HC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuron fate specification|
|neuron fate commitment|
|cell fate specification|
|chromosome|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron development|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|neuron differentiation|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.93|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.9|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.8|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.7|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.7|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.81|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.82|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.86|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.89|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.92|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.21|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.523|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.498|
|[[:human genes:c:c14orf93|C14orf93]]|0.497|
|[[:human genes:r:rrm1|RRM1]]|0.494|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.492|
|[[:human genes:d:disp2|DISP2]]|0.492|
|[[:human genes:r:rps2|RPS2]]|0.486|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.484|
|[[:human genes:c:ccna2|CCNA2]]|0.477|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.475|
|[[:human genes:k:kif3c|KIF3C]]|0.473|
|[[:human genes:n:nop16|NOP16]]|0.471|
|[[:human genes:v:vasn|VASN]]|0.466|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.465|
|[[:human genes:m:myo1h|MYO1H]]|0.463|
|[[:human genes:n:npipb5|NPIPB5]]|0.463|
|[[:human genes:o:orc6|ORC6]]|0.462|
|[[:human genes:e:exosc5|EXOSC5]]|0.462|
|[[:human genes:t:tceb3c|TCEB3C]]|0.462|
|[[:human genes:s:supt5h|SUPT5H]]|0.46|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.458|
|[[:human genes:t:trim52|TRIM52]]|0.457|
|[[:human genes:a:akirin2|AKIRIN2]]|0.452|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.447|
|[[:human genes:d:ddtl|DDTL]]|0.447|
|[[:human genes:s:sec13|SEC13]]|0.445|
|[[:human genes:p:pola1|POLA1]]|0.442|
|[[:human genes:d:ddx51|DDX51]]|0.44|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.438|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.438|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.438|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.438|
|[[:human genes:a:atp1a3|ATP1A3]]|0.438|
|[[:human genes:p:paf1|PAF1]]|0.437|
|[[:human genes:p:polr2f|POLR2F]]|0.436|
|[[:human genes:c:crnkl1|CRNKL1]]|0.436|
|[[:human genes:n:napa|NAPA]]|0.435|
|[[:human genes:r:rad51|RAD51]]|0.433|
|[[:human genes:s:stil|STIL]]|0.431|
|[[:human genes:s:slc6a17|SLC6A17]]|0.431|
|[[:human genes:c:cbwd5|CBWD5]]|0.43|
|[[:human genes:c:cbwd3|CBWD3]]|0.428|
|[[:human genes:r:rps12|RPS12]]|0.428|
|[[:human genes:r:rbbp5|RBBP5]]|0.424|
|[[:human genes:c:copg1|COPG1]]|0.423|
|[[:human genes:s:sez6l2|SEZ6L2]]|0.422|
|[[:human genes:h:hivep3|HIVEP3]]|0.421|
|[[:human genes:m:madcam1|MADCAM1]]|0.421|
|[[:human genes:a:atxn1|ATXN1]]|0.42|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.418|
|[[:human genes:p:plk4|PLK4]]|0.417|
|[[:human genes:f:fam25b|FAM25B]]|0.416|
|[[:human genes:s:snrpa1|SNRPA1]]|0.415|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.414|
|[[:human genes:a:ankle2|ANKLE2]]|0.413|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.413|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.413|
|[[:human genes:a:aamp|AAMP]]|0.413|
|[[:human genes:p:pole|POLE]]|0.411|
|[[:human genes:p:pwp2|PWP2]]|0.41|
|[[:human genes:l:lad1|LAD1]]|0.41|
|[[:human genes:w:wdr87|WDR87]]|0.41|
|[[:human genes:s:sf3a1|SF3A1]]|0.409|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.409|
|[[:human genes:t:tra2b|TRA2B]]|0.409|
|[[:human genes:e:exosc6|EXOSC6]]|0.409|
|[[:human genes:s:smg7|SMG7]]|0.406|
|[[:human genes:d:dtl|DTL]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:s:ssh2|SSH2]]|0.405|
|[[:human genes:p:psmd11|PSMD11]]|0.404|
|[[:human genes:p:psmb4|PSMB4]]|0.403|
|[[:human genes:p:psma6|PSMA6]]|0.402|
|[[:human genes:c:cwc22|CWC22]]|0.401|
|[[:human genes:c:cacna1a|CACNA1A]]|0.401|
|[[:human genes:p:psmd1|PSMD1]]|0.401|
|[[:human genes:m:mt1e|MT1E]]|0.401|
|[[:human genes:m:myb|MYB]]|0.4|
|[[:human genes:t:ttc1|TTC1]]|0.4|
|[[:human genes:n:nup54|NUP54]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2035
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYT1L Expression in NALM6 Cells: 2.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>