CSNK1A1

Gene Information

Official Symbol: CSNK1A1
Official Name: casein kinase 1 alpha 1
Aliases and Previous Symbols: N/A
Entrez ID: 1452
UniProt: P48729
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cincreasin 100μM R08 exp473	1.72
Epigallocatechin gallate 20μM R05 exp230	1.72
Tozasertib 0.1μM R07 exp414	1.72
YM155 0.0002μM R01 exp61	1.78
Nifuroxazide 1μM R01 exp51	1.79
Wortmannin 5μM R00 exp38	1.81
Pifithrin-alpha 20μM R07 exp390	1.82
ABT-702 5μM R07 exp318	1.97
Nicotinamide 2000μM R01 exp50	2.11
MS094 2μM R03 exp136	2.22
A-395N 10μM R05 exp219	2.67
Fas-L 44ng/ml R08 exp482	2.74
Parthenolide 2.5μM R05 exp238	2.85

Gene	Correlation
SEC13	0.427
SSH2	0.421
NUPL1	0.42
PLA2G4F	0.418
TCEB3C	0.416
PSMD1	0.415
FAM25B	0.409
TCEB3CL2	0.405
NBPF16	0.404
ATP6V1C1	0.403
PSMD3	0.403
TBC1D3G	0.401
PSMC4	0.4

Global Fraction of Cell Lines Where Essential: 42/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	0/26
breast	4/33
central nervous system	4/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	3/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 181
Expression level (log2 read counts): 5.9

Expression Distribution

Pkinase Tyr
Pkinase

beta-catenin destruction complex assembly
regulation of GTP binding
beta-catenin destruction complex
mRNA cleavage and polyadenylation specificity factor complex
beta-catenin destruction complex disassembly
intermediate filament cytoskeleton organization
intermediate filament-based process
kinase activity
peptidyl-threonine phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
condensed chromosome kinetochore
canonical Wnt signaling pathway
peptidyl-threonine modification
positive regulation of ubiquitin-dependent protein catabolic process
keratin filament
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
Golgi organization
ciliary basal body
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
ribonucleoprotein complex
negative regulation of canonical Wnt signaling pathway
peptidyl-serine phosphorylation
regulation of proteasomal protein catabolic process
cilium
peptidyl-serine modification
negative regulation of Wnt signaling pathway
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
protein kinase activity
protein-containing complex disassembly
regulation of cellular protein catabolic process
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
positive regulation of proteolysis
Wnt signaling pathway
regulation of Wnt signaling pathway
protein serine/threonine kinase activity