CSNK1A1 [The Human Chemical-Genetic Interaction Map Project]

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======= CSNK1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSNK1A1
  * **<color #00a2e8>Official Name</color>**: casein kinase 1 alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1452|1452]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48729|P48729]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSNK1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSNK1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-catenin destruction complex assembly|
|regulation of GTP binding|
|beta-catenin destruction complex|
|mRNA cleavage and polyadenylation specificity factor complex|
|beta-catenin destruction complex disassembly|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|kinase activity|
|peptidyl-threonine phosphorylation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|condensed chromosome kinetochore|
|canonical Wnt signaling pathway|
|peptidyl-threonine modification|
|positive regulation of ubiquitin-dependent protein catabolic process|
|keratin filament|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|Golgi organization|
|ciliary basal body|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|ribonucleoprotein complex|
|negative regulation of canonical Wnt signaling pathway|
|peptidyl-serine phosphorylation|
|regulation of proteasomal protein catabolic process|
|cilium|
|peptidyl-serine modification|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|protein kinase activity|
|protein-containing complex disassembly|
|regulation of cellular protein catabolic process|
|regulation of canonical Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of protein catabolic process|
|cellular component disassembly|
|nuclear speck|
|endomembrane system organization|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|centrosome|
|cell division|
|cell morphogenesis|
|regulation of proteolysis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of catabolic process|
|cytoskeleton organization|
|cell-cell signaling|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|ATP binding|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.72|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.78|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.79|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.81|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.82|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.97|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.11|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.22|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.67|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.74|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sec13|SEC13]]|0.427|
|[[:human genes:s:ssh2|SSH2]]|0.421|
|[[:human genes:n:nupl1|NUPL1]]|0.42|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.418|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:p:psmd1|PSMD1]]|0.415|
|[[:human genes:f:fam25b|FAM25B]]|0.409|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.405|
|[[:human genes:n:nbpf16|NBPF16]]|0.404|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.403|
|[[:human genes:p:psmd3|PSMD3]]|0.403|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.401|
|[[:human genes:p:psmc4|PSMC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 42/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|0/26|
|breast|4/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 181
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSNK1A1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>