Cincreasin 100μM R08 exp473 [The Human Chemical-Genetic Interaction Map Project]

Inhibits budding yeast Mps1 but not human MPS1 (TTK), overrides spindle checkpoint

Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor
Class / Subclass 3: Cell Cycle / Actin Inhibitor

Compound References

PubChem Name: 6-Bromo-2-benzoxazolinone
Synonyms: N/A
CAS #: 19932-85-5
PubChem CID: 29859
IUPAC: 6-bromo-3H-1,3-benzoxazol-2-one
INCHI Name: InChI=1S/C7H4BrNO2/c8-4-1-2-5-6(3-4)11-7(10)9-5/h1-3H,(H,9,10)
INCHI Key: DDNKJFBQMQOIKI-UHFFFAOYSA-N
Molecular Weight: 214.02
Canonical SMILES: C1=CC2=C(C=C1Br)OC(=O)N2
Isomeric SMILES: N/A
Molecular Formula: C7H4BrNO2

Compound Supplier

Supplier Name: Combi-Blocks
Catalog #: HI-1909
Lot #: B75436

Compound Characterization

LCMS: Tr 1.16 min, m/z 212- [M-H]-

Dose Response Curve

Platform ID: Cincreasin
Min: -10.4527; Max: 28.7557

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 08
Dose: 100µM
Days of incubation: 8
Doublings: 6.5
Numbers of reads: 20599152

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
1/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
KDSR	-3.07	<0.01
TRIM44	-2.62	0.11
CHKA	-2.62	0.08
TMED10	-2.59	0.08
AUP1	-2.47	0.37
CYP1A1	-2.43	0.12
DYNC1H1	-2.24	0.83
DPAGT1	-2.22	0.45
JTB	-2.17	0.37
GPR107	-2.15	0.37
SARS	-2.15	0.90
GPN1	-2.15	0.52
SLIT1	-2.13	0.52
IQCD	-2.00	0.52
YARS	-2.00	0.83
P2RY2	-2.00	0.52
NOSTRIN	-1.99	0.52
CHTOP	-1.94	0.69
ALG3	-1.91	0.62
TUBA1C	-1.91	0.79
LAMTOR4	-1.91	0.62
TBK1	-1.90	0.62
ALG12	-1.89	0.62
SYT10	-1.89	0.62
PPP1R1B	-1.89	0.62
SLC39A10	-1.88	0.63
MBTPS2	-1.87	0.63
MAGI2	-1.85	0.79
FETUB	-1.84	0.69
RER1	-1.83	0.69
CHAF1A	1.83	0.80
OR5R1	1.83	0.76
RPS13	1.85	0.80
RPS15A	1.85	0.83
KRTAP4-1	1.85	0.76
DTX3	1.86	0.80
CNGB3	1.90	0.66
PSMD7	1.91	0.80
REV1	1.92	0.65
INTS6	1.93	0.80
EPPIN	1.94	0.65
MST4	1.95	0.65
FAM179A	1.97	0.76
SLC6A17	2.01	0.66
PSMC3	2.02	0.80
DEPDC4	2.04	0.65
SDHB	2.04	0.57
MIR205HG	2.08	0.80
CDKL1	2.10	0.53
KIAA0355	2.10	0.65
HAT1	2.11	0.53
KRTAP9-9	2.15	0.57
EXOSC3	2.17	0.57
TINF2	2.18	0.65
TMEM174	2.22	0.53
FRMD1	2.24	0.47
RPN2	2.29	0.47
EXOSC9	2.29	0.47
ATP8B2	2.49	0.47
NUP214	2.53	0.47

Last modified: 2026/01/15 21:36
by 127.0.0.1