P2RY2

Entrez Summary: N/A
UniProt Summary: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S » 2-methylthio-ATP = ADP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mucus secretion
regulation of mucus secretion
G protein-coupled purinergic nucleotide receptor activity
G protein-coupled purinergic nucleotide receptor signaling pathway
cellular response to ATP
G protein-coupled purinergic receptor signaling pathway
purinergic nucleotide receptor signaling pathway
purinergic receptor signaling pathway
response to ATP
cellular response to nutrient
phospholipase C-activating G protein-coupled receptor signaling pathway
response to organophosphorus
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
response to purine-containing compound
vascular process in circulatory system
signaling receptor activity
response to nutrient
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
blood circulation
circulatory system process
cellular response to drug
positive regulation of secretion
regulation of body fluid levels
response to nutrient levels
regulation of anatomical structure size
response to extracellular stimulus
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular ion homeostasis
cellular response to nitrogen compound
cellular chemical homeostasis
ion homeostasis
regulation of secretion
cellular homeostasis
response to organic cyclic compound
positive regulation of transport