NUP214

Entrez Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
UniProt Summary: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. {ECO:0000303|PubMed:8108440}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-1.84
Heregulin-B 44ng/ml R08 exp486	1.77
Tenofovir 10μM R07 exp405	1.78
Calcipotriol 5μM R08 exp464	1.86
Geldanamycin 0.01μM R05 exp235	1.87
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.89
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.98
Menadione 5μM R06 exp292	2.04
Rapamycin 1μM R00 exp29	2.32
Cincreasin 100μM R08 exp473	2.53

Global Fraction of Cell Lines Where Essential: 267/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	8/28
bone	14/26
breast	15/33
central nervous system	27/56
cervix	0/4
colorectal	9/17
esophagus	1/13
fibroblast	1/1
gastric	6/16
kidney	4/21
liver	7/20
lung	34/75
lymphocyte	9/16
ovary	16/26
pancreas	7/24
peripheral nervous system	5/16
plasma cell	3/15
prostate	0/1
skin	7/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	9/29
uterus	3/5

Expression Distribution

cytoplasmic side of nuclear pore
nuclear export signal receptor activity
nuclear localization sequence binding
structural constituent of nuclear pore
tRNA export from nucleus
tRNA-containing ribonucleoprotein complex export from nucleus
tRNA transport
ncRNA export from nucleus
intracellular transport of virus
host cell
transport of virus
protein sumoylation
multi-organism localization
multi-organism transport
nuclear pore
regulation of glycolytic process
regulation of cellular response to heat
regulation of gene silencing by miRNA
regulation of carbohydrate catabolic process
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
protein import into nucleus
regulation of nucleocytoplasmic transport
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
import into nucleus
viral transcription
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
regulation of gene silencing
viral gene expression
protein import
protein export from nucleus
mRNA transport
nuclear export
regulation of generation of precursor metabolites and energy