YARS

Entrez Summary: N/A
UniProt Summary: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-2.62
WNT3A 44ng/ml R08 exp537	-2.51
HMS-I1 1μM R01 exp46	-2.3
I-BRD9 4μM R07 exp365	-2.08
Rapamycin 2μM R07 exp306	-2.05
Cincreasin 100μM R08 exp473	-2
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.83
BI-6727 0.001μM R01 exp42	-1.72
Etoposide 0.1μM R05 exp198	-1.7
42°C R08 exp539	1.71
Sulforaphane 9μM R08 exp526 no dilution day6	1.71
CFI-400945 25μM R08 exp469	1.72
Bafilomycin-A1 0.009μM R08 exp454	1.76
TIC10 10μM R08 exp532	1.84
Ammonium tetrathiomolybdate 10μM R08 exp448	1.86
DABN 20μM R00 exp17	1.86
UM0129480 7μM R02 exp85	1.9
Mitomycin-C 0.06μM R08 exp503	1.92
BI-2536 0.02μM R03 exp96	1.93
Vinblastine 0.2μM R03 exp108	2.02
DABN racemic mixture R03 exp93	2.07
MLN-4924 2μM R00 exp22	2.13
Nocodazole 0.2μM R00 exp24	2.16
Tanespimycin 14μM R08 exp527	2.2
GSK461364A 0.1μM R03 exp126	2.31
BVD-523 15μM R02 exp67	2.53
Pimelic-diphenylamide-106 5μM R00 exp28	2.54

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

tRNA bind
tRNA-synt 1b

tyrosine-tRNA ligase activity
tyrosyl-tRNA aminoacylation
interleukin-8 receptor binding
aminoacyl-tRNA synthetase multienzyme complex
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
tRNA metabolic process
nuclear body
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
apoptotic process
oxoacid metabolic process
organic acid metabolic process
programmed cell death
cell death
RNA binding
organonitrogen compound biosynthetic process
ATP binding
extracellular space
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression