OTUD5

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Disulfiram 4.3μM R06 exp281	-2.39
Tubastatin-A 2.5μM R07 exp417	-2.22
HMS-I2 10μM R06 exp288	-2.17
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2
Hypoxia 5%O2 R04 exp191	-1.9
THZ531 0.11μM R07 exp409	-1.89
Rapamycin 2μM R07 exp306	-1.82
Dimethyloxaloylglycine 100μM R05 exp229	-1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.72
UMK57 1μM R01 exp59	1.72
BVD-523 15μM R02 exp67	1.73
Oligomycin-A 20μM R00 exp26	1.73
Bleomycin 5μM R08 exp459	1.98
Rotenone 2μM R00 exp33	2.08
Actinomycin-D 0.001μM R00 exp3	2.26
Taxol 0.004μM R03 exp103	2.34
Etoposide 1μM R00 exp19	2.36
42°C R08 exp539	2.37
Pimelic-diphenylamide-106 5μM R00 exp28	2.63
BML-284 0.09μM R08 exp460	2.66
Actinomycin-D 0.01μM R00 exp4	2.81
5-Fluorouracil 20μM R00 exp2	2.87
MLN-4924 2μM R00 exp22	3.11
UM131593 0.2μM R03 exp106	3.38

Global Fraction of Cell Lines Where Essential: 42/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	2/28
blood	0/26
bone	3/26
breast	3/30
central nervous system	1/49
cervix	0/4
colorectal	1/17
esophagus	1/11
fibroblast	0/1
gastric	1/14
kidney	2/18
liver	2/19
lung	2/72
lymphocyte	0/16
ovary	2/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	2/12
prostate	1/1
skin	2/20
soft tissue	0/9
thyroid	1/2
upper aerodigestive	4/22
urinary tract	0/28
uterus	1/5

Expression Distribution

ubiquitinyl hydrolase activity
Lys63-specific deubiquitinase activity
Lys48-specific deubiquitinase activity
protein K63-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of type I interferon production
thiol-dependent ubiquitin-specific protease activity
regulation of type I interferon production
negative regulation of cytokine production
protein deubiquitination
protein modification by small protein removal
response to lipopolysaccharide
response to molecule of bacterial origin
response to bacterium
regulation of cytokine production
response to lipid
protein modification by small protein conjugation or removal
negative regulation of multicellular organismal process
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
response to oxygen-containing compound