MLLT1

Gene Information

Official Symbol: MLLT1
Official Name: MLLT1 super elongation complex subunit
Aliases and Previous Symbols: N/A
Entrez ID: 4298
UniProt: Q03111
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-769662 20μM R07 exp331	-1.75
Vinblastine 0.2μM R03 exp108	1.72
Doxorubicin 0.02μM R08 exp478	2.16
Nocodazole 0.1μM R03 exp94	2.2
THZ1 0.06μM R08 exp531	2.4
UM131593 0.2μM R03 exp106	3.26

Gene	Correlation
MED23	0.654
CCDC101	0.652
THOC6	0.606
RPTOR	0.596
WDR24	0.589
MED16	0.583
GNB1L	0.578
TRIM28	0.573
TAF5L	0.561
ZNF592	0.559
DHX29	0.558
TLE4	0.554
UBE2G1	0.552
MED13	0.549
OTUD5	0.545
TTI2	0.539
MEAF6	0.532
TAF6L	0.531
VMP1	0.529
BRPF1	0.528
TTI1	0.524
TADA1	0.524
MED13L	0.52
RNMT	0.517
ZNF608	0.516
DOHH	0.516
DPAGT1	0.515
RTCB	0.513
ATF7IP	0.512
HHEX	0.51
GMPPB	0.507
MAX	0.506
TMEM41B	0.504
FBXO11	0.503
PELO	0.499
AARS	0.498
SUPT7L	0.497
GFPT1	0.494
UBE3A	0.491
MED25	0.49
MTOR	0.49
MAPK14	0.489
PMM2	0.487
CSNK2B	0.487
PAX5	0.482
CBX3	0.479
HARS	0.478
VHL	0.477
DNAJC3	0.475
LAMTOR4	0.474
WDR59	0.473
CBFB	0.47
POLR3H	0.469
UHRF1	0.468
BAP1	0.468
UBR5	0.465
ALG13	0.464
FLI1	0.46
XPO6	0.457
MED4	0.456
TADA2B	0.456
TRMT5	0.454
EIF4E	0.454
ALG1	0.451
UBE2G2	0.449
VCPIP1	0.445
UAP1	0.444
USP22	0.444
TADA3	0.444
UBE2L3	0.439
LAMTOR5	0.438
TCEB3	0.437
GTF3C4	0.436
ALG5	0.436
TELO2	0.436
LSMD1	0.434
ATP5J	0.434
HSPD1	0.431
NSD1	0.431
THG1L	0.43
SETDB1	0.429
ID3	0.429
GTF3C2	0.429
DCAF7	0.428
PRKAR1A	0.428
ADSL	0.427
PAM16	0.425
TRIAP1	0.424
TP53	0.423
SUPT20H	0.422
NAE1	0.422
SLC35B1	0.422
MED10	0.419
GTF3C6	0.418
ARIH1	0.416
RPS6KB1	0.416
OIP5	0.414
LSM11	0.411
GTF3C3	0.411
TSEN54	0.41
ALG2	0.409
TRNT1	0.408
MIOS	0.408
YARS	0.408
MAML1	0.407
EXOC4	0.407
DR1	0.406
POLR3B	0.405
CARS	0.404
GPN2	0.404
UBE2J1	0.404
ELF2	0.403
RPN1	0.402
SMARCD1	0.402
ARL14EP	0.402
SCAF8	0.402
ZFX	0.401
EPRS	0.401
SPTY2D1	0.4

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1941
Expression level (log2 read counts): 6.58

Expression Distribution

transcription elongation factor complex
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
fibrillar center
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
transcription by RNA polymerase II
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
nucleobase-containing compound biosynthetic process
negative regulation of protein metabolic process
negative regulation of molecular function
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
regulation of protein phosphorylation
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of phosphorylation
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
gene expression