ARIH1

Gene Information

Official Symbol: ARIH1
Official Name: ariadne RBR E3 ubiquitin protein ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 25820
UniProt: Q9Y4X5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:27565346}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CVT-10216 0.1μM R06 exp278	-3.02
Disulfiram 4.3μM R06 exp281	-2.69
PFI-2 4μM R05 exp239	-2.42
LLY-284 2.6μM R06 exp291	-2.32
Colchicine 0.009μM R05 exp215	-2.02
Glyphosate 1000μM R06 exp283	-2.02
Vemurafenib 6.6μM R02 exp89	-2.02
Apcin 25μM plus proTAME 2μM R04 exp177	-1.93
Docosahexaenoic-acid 50μM R07 exp356	-1.93
UM0131023 0.05μM R05 exp248	-1.86
Arsenate 40μM R06 exp264	-1.83
CB-5083 0.4μM R08 exp468	-1.82
Senexin-A 25μM R07 exp400	-1.82
INK128 0.2μM R02 exp70	-1.79
Daidzin 10μM R06 exp280	-1.77
Centrinone 0.5μM R07 exp343	-1.76
Tozasertib 0.1μM R07 exp414	-1.75
Cycloheximide 0.02μM R00 exp14	-1.74
LLY-283 2.6μM R06 exp290	-1.73
Nocodazole 0.1μM R03 exp94	1.8
UMK57 1μM R01 exp59	3.02

Gene	Correlation
MAPK14	0.469
UBE2L3	0.457
CCDC101	0.445
ATF7IP	0.433
CBFB	0.423
MLLT1	0.416
UBE3A	0.415
FNTA	0.405
TAF5L	0.402
MED23	0.402
RNMT	0.401
AARS	0.401

Global Fraction of Cell Lines Where Essential: 676/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	24/28
blood	25/28
bone	24/26
breast	30/33
central nervous system	53/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	18/21
liver	18/20
lung	70/75
lymphocyte	15/16
ovary	24/26
pancreas	23/24
peripheral nervous system	11/16
plasma cell	15/15
prostate	1/1
skin	20/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	27/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 2088
Expression level (log2 read counts): 7.15

Expression Distribution

Lewy body
ubiquitin-like protein transferase activity
Cul4A-RING E3 ubiquitin ligase complex
Cul2-RING ubiquitin ligase complex
ubiquitin conjugating enzyme binding
Cul3-RING ubiquitin ligase complex
Cajal body
SCF ubiquitin ligase complex
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
ubiquitin ligase complex
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
regulation of cellular protein catabolic process
nuclear body
ubiquitin protein ligase binding
protein polyubiquitination
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
zinc ion binding