MAPK14
Gene Information
- Official Symbol: MAPK14
- Official Name: mitogen-activated protein kinase 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 1432
- UniProt: Q16539
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
GO Terms
| positive regulation of interleukin-12 secretion |
| regulation of synaptic membrane adhesion |
| NFAT protein binding |
| mitogen-activated protein kinase p38 binding |
| p38MAPK cascade |
| positive regulation of metallopeptidase activity |
| positive regulation of cytokine secretion involved in immune response |
| regulation of interleukin-12 secretion |
| stress-induced premature senescence |
| positive regulation of brown fat cell differentiation |
| cellular response to lipoteichoic acid |
| response to lipoteichoic acid |
| regulation of metallopeptidase activity |
| MAP kinase activity |
| positive regulation of macrophage chemotaxis |
| regulation of cytokine secretion involved in immune response |
| regulation of brown fat cell differentiation |
| MAP kinase kinase activity |
| response to muscle stretch |
| 3-UTR-mediated mRNA stabilization |
| positive regulation of myoblast fusion |
| response to muramyl dipeptide |
| cartilage condensation |
| positive regulation of macrophage migration |
| regulation of myoblast fusion |
| cell aggregation |
| positive regulation of myoblast differentiation |
| positive regulation of cyclase activity |
| positive regulation of cardiac muscle cell proliferation |
| regulation of macrophage chemotaxis |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| positive regulation of erythrocyte differentiation |
| cellular senescence |
| cellular response to virus |
| positive regulation of myotube differentiation |
| positive regulation of cardiac muscle tissue growth |
| lipopolysaccharide-mediated signaling pathway |
| positive regulation of interleukin-12 production |
| positive regulation of protein import into nucleus |
| regulation of macrophage migration |
| positive regulation of heart growth |
| positive regulation of glucose import |
| positive regulation of protein import |
| cellular response to vascular endothelial growth factor stimulus |
| regulation of cytokine production involved in inflammatory response |
| regulation of cardiac muscle cell proliferation |
| regulation of cyclase activity |
| regulation of granulocyte chemotaxis |
| mRNA stabilization |
| positive regulation of glucose transmembrane transport |
| osteoclast differentiation |
| positive regulation of cardiac muscle tissue development |
| regulation of mononuclear cell migration |
| regulation of erythrocyte differentiation |
| positive regulation of organ growth |
| RNA stabilization |
| negative regulation of mRNA catabolic process |
| regulation of myoblast differentiation |
| regulation of interleukin-12 production |
| positive regulation of cytokine production involved in immune response |
| regulation of glucose import |
| regulation of protein import into nucleus |
| positive regulation of blood vessel endothelial cell migration |
| regulation of myotube differentiation |
| regulation of cardiac muscle tissue growth |
| positive regulation of striated muscle cell differentiation |
| regulation of protein import |
| negative regulation of RNA catabolic process |
| positive regulation of fat cell differentiation |
| positive regulation of nucleocytoplasmic transport |
| regulation of heart growth |
| cell aging |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| cellular response to ionizing radiation |
| positive regulation of muscle tissue development |
| regulation of glucose transmembrane transport |
| positive regulation of protein localization to nucleus |
| fatty acid oxidation |
| lipid oxidation |
| negative regulation of mRNA metabolic process |
| regulation of cardiac muscle tissue development |
| chondrocyte differentiation |
| regulation of cytokine production involved in immune response |
| protein phosphatase binding |
| positive regulation of muscle cell differentiation |
| positive regulation of leukocyte chemotaxis |
| regulation of blood vessel endothelial cell migration |
| positive regulation of myeloid cell differentiation |
| regulation of organ growth |
| positive regulation of reactive oxygen species metabolic process |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of endothelial cell migration |
| regulation of striated muscle cell differentiation |
| signal transduction in response to DNA damage |
| stress-activated MAPK cascade |
| regulation of nucleocytoplasmic transport |
| myeloid leukocyte differentiation |
| regulation of leukocyte chemotaxis |
| glucose metabolic process |
| secretory granule lumen |
| regulation of protein localization to nucleus |
| spindle pole |
| regulation of fat cell differentiation |
| skeletal muscle tissue development |
| ficolin-1-rich granule lumen |
| positive regulation of leukocyte migration |
| DNA damage checkpoint |
| regulation of striated muscle tissue development |
| skeletal muscle organ development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| positive regulation of chemotaxis |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| positive regulation of epithelial cell migration |
| stress-activated protein kinase signaling cascade |
| DNA integrity checkpoint |
| response to ionizing radiation |
| placenta development |
| regulation of muscle cell differentiation |
| positive regulation of intracellular protein transport |
| activation of MAPK activity |
| hexose metabolic process |
| regulation of endothelial cell migration |
| positive regulation of developmental growth |
| cartilage development |
| peptidyl-serine phosphorylation |
| negative regulation of canonical Wnt signaling pathway |
| cellular response to radiation |
| regulation of mRNA stability |
| regulation of reactive oxygen species metabolic process |
| regulation of signal transduction by p53 class mediator |
| regulation of RNA stability |
| cellular response to lipopolysaccharide |
| positive regulation of hemopoiesis |
| regulation of ossification |
| positive regulation of peptidase activity |
| cellular response to molecule of bacterial origin |
| cell cycle checkpoint |
| regulation of leukocyte migration |
| peptidyl-serine modification |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| monosaccharide metabolic process |
| striated muscle cell differentiation |
| regulation of mRNA catabolic process |
| lipid modification |
| positive regulation of transmembrane transport |
| regulation of cytokine secretion |
| positive regulation of intracellular transport |
| negative regulation of Wnt signaling pathway |
| regulation of chemotaxis |
| response to mechanical stimulus |
| cellular response to biotic stimulus |
| regulation of synapse organization |
| positive regulation of immune effector process |
| regulation of epithelial cell migration |
| myeloid cell differentiation |
| connective tissue development |
| regulation of myeloid cell differentiation |
| regulation of synapse structure or activity |
| regulation of intracellular protein transport |
| skeletal system morphogenesis |
| cellular response to tumor necrosis factor |
| muscle cell differentiation |
| Ras protein signal transduction |
| negative regulation of cellular catabolic process |
| positive regulation of growth |
| positive regulation of MAP kinase activity |
| response to tumor necrosis factor |
| positive regulation of protein secretion |
| aging |
| response to virus |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| positive regulation of peptide secretion |
| muscle organ development |
| muscle tissue development |
| negative regulation of catabolic process |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| response to lipopolysaccharide |
| angiogenesis |
| small GTPase mediated signal transduction |
| fatty acid metabolic process |
| positive regulation of cellular protein localization |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| regulation of mRNA metabolic process |
| regulation of developmental growth |
| leukocyte differentiation |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| enzyme binding |
| glutamatergic synapse |
| regulation of intracellular transport |
| positive regulation of proteolysis |
| regulation of Wnt signaling pathway |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| nuclear speck |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| reproductive structure development |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| positive regulation of secretion |
| response to radiation |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| response to peptide |
| carbohydrate metabolic process |
| muscle structure development |
| blood vessel development |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| skeletal system development |
| regulation of peptide secretion |
| neutrophil mediated immunity |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| leukocyte degranulation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| cardiovascular system development |
| cellular response to lipid |
| myeloid cell activation involved in immune response |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| monocarboxylic acid metabolic process |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of MAPK cascade |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| hemopoiesis |
| regulation of transmembrane transport |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| immune system development |
| tube morphogenesis |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| regulation of growth |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| regulated exocytosis |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| tube development |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cellular localization |
| apoptotic process |
| leukocyte activation |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of catabolic process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| organic acid metabolic process |
| regulation of protein localization |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CCDC101 | 0.562 |
| THOC6 | 0.551 |
| RPTOR | 0.543 |
| GTF3C2 | 0.543 |
| RNMT | 0.538 |
| AARS | 0.537 |
| ALG5 | 0.536 |
| SRP68 | 0.519 |
| GNB1L | 0.515 |
| GMPPB | 0.51 |
| PMM2 | 0.509 |
| WDR24 | 0.503 |
| TTI2 | 0.498 |
| OTUD5 | 0.497 |
| MED16 | 0.495 |
| MLLT1 | 0.489 |
| TTI1 | 0.486 |
| ENY2 | 0.481 |
| CBFB | 0.478 |
| TELO2 | 0.477 |
| ARIH1 | 0.469 |
| CSNK2B | 0.469 |
| DPAGT1 | 0.468 |
| RTCB | 0.467 |
| MTOR | 0.467 |
| ATF7IP | 0.463 |
| MED23 | 0.462 |
| LAMTOR4 | 0.462 |
| CBX3 | 0.455 |
| THG1L | 0.455 |
| NARS | 0.451 |
| DNAJC3 | 0.451 |
| TLE4 | 0.451 |
| ELAC2 | 0.451 |
| TRMT5 | 0.449 |
| ALG1 | 0.448 |
| LAMTOR5 | 0.447 |
| CCT7 | 0.447 |
| TAF5L | 0.446 |
| ATP5J | 0.446 |
| NXT1 | 0.445 |
| HARS | 0.445 |
| LSMD1 | 0.44 |
| MAP3K4 | 0.439 |
| EIF4E | 0.438 |
| XPOT | 0.437 |
| TMEM41B | 0.435 |
| RPE | 0.432 |
| DOHH | 0.432 |
| TRIAP1 | 0.432 |
| NUPL2 | 0.432 |
| UHRF1 | 0.43 |
| ADSL | 0.429 |
| PAX5 | 0.427 |
| DPF2 | 0.426 |
| UBE2G1 | 0.425 |
| SSBP2 | 0.425 |
| UBE2L3 | 0.425 |
| MED4 | 0.423 |
| TBP | 0.422 |
| MAX | 0.422 |
| SRP72 | 0.42 |
| ALG13 | 0.417 |
| DERL2 | 0.417 |
| ALG6 | 0.416 |
| VRK1 | 0.415 |
| LSM11 | 0.414 |
| UBA3 | 0.413 |
| B3GNT2 | 0.413 |
| MEAF6 | 0.412 |
| GTF3C3 | 0.411 |
| YARS | 0.409 |
| POLR3H | 0.406 |
| PELO | 0.405 |
| GFPT1 | 0.404 |
| GTF3C4 | 0.404 |
| OSGEP | 0.403 |
| ZC3H11A | 0.402 |
| TCEB3 | 0.402 |
| NAA20 | 0.402 |
| ALG2 | 0.402 |
| TADA1 | 0.401 |
| UBE3A | 0.401 |
| SUPT7L | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5214
- Expression level (log2 read counts): 6.99
Expression Distribution
MAPK14 Expression in NALM6 Cells: 6.99
