B3GNT2

Official Symbol: B3GNT2
Official Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 10678
UniProt: Q9NY97
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:9892646}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
poly-N-acetyllactosamine biosynthetic process
poly-N-acetyllactosamine metabolic process
galactosyltransferase activity
acetylgalactosaminyltransferase activity
keratan sulfate biosynthetic process
keratan sulfate metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
O-glycan processing
cellular polysaccharide metabolic process
polysaccharide metabolic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
protein O-linked glycosylation
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
sulfur compound biosynthetic process
protein glycosylation
macromolecule glycosylation
axon guidance
neuron projection guidance
glycosylation
glycoprotein biosynthetic process
sulfur compound metabolic process
axonogenesis
glycoprotein metabolic process
axon development
cell morphogenesis involved in neuron differentiation
sensory perception of smell
carbohydrate metabolic process
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis