B3GNT2 [The Human Chemical-Genetic Interaction Map Project]

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======= B3GNT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B3GNT2
  * **<color #00a2e8>Official Name</color>**: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10678|10678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY97|Q9NY97]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B3GNT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B3GNT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605581|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:9892646}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Galactosyl T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|
|poly-N-acetyllactosamine biosynthetic process|
|poly-N-acetyllactosamine metabolic process|
|galactosyltransferase activity|
|acetylgalactosaminyltransferase activity|
|keratan sulfate biosynthetic process|
|keratan sulfate metabolic process|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|cellular carbohydrate biosynthetic process|
|O-glycan processing|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|protein O-linked glycosylation|
|carbohydrate biosynthetic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|sulfur compound biosynthetic process|
|protein glycosylation|
|macromolecule glycosylation|
|axon guidance|
|neuron projection guidance|
|glycosylation|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|axonogenesis|
|glycoprotein metabolic process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|sensory perception of smell|
|carbohydrate metabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|sensory perception of chemical stimulus|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|sensory perception|
|Golgi apparatus|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|endoplasmic reticulum|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|nervous system process|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.11|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.01|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.78|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.71|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.8|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mgat1|MGAT1]]|0.495|
|[[:human genes:w:wdr20|WDR20]]|0.456|
|[[:human genes:m:mapk14|MAPK14]]|0.413|
|[[:human genes:t:tbp|TBP]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B3GNT2 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>