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Ask your administrator if you think this is wrong. ======= MAPK14 ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: MAPK14 * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 14 * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1432|1432]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16539|Q16539]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK14&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK14|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600289|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: N/A * **<color #00a2e8>UniProt Summary</color>**: N/A <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |Pkinase| |Pkinase Tyr| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |positive regulation of interleukin-12 secretion| |regulation of synaptic membrane adhesion| |NFAT protein binding| |mitogen-activated protein kinase p38 binding| |p38MAPK cascade| |positive regulation of metallopeptidase activity| |positive regulation of cytokine secretion involved in immune response| |regulation of interleukin-12 secretion| |stress-induced premature senescence| |positive regulation of brown fat cell differentiation| |cellular response to lipoteichoic acid| |response to lipoteichoic acid| |regulation of metallopeptidase activity| |MAP kinase activity| |positive regulation of macrophage chemotaxis| |regulation of cytokine secretion involved in immune response| |regulation of brown fat cell differentiation| |MAP kinase kinase activity| |response to muscle stretch| |3-UTR-mediated mRNA stabilization| |positive regulation of myoblast fusion| |response to muramyl dipeptide| |cartilage condensation| |positive regulation of macrophage migration| |regulation of myoblast fusion| |cell aggregation| |positive regulation of myoblast differentiation| |positive regulation of cyclase activity| |positive regulation of cardiac muscle cell proliferation| |regulation of macrophage chemotaxis| |positive regulation of syncytium formation by plasma membrane fusion| |regulation of syncytium formation by plasma membrane fusion| |positive regulation of erythrocyte differentiation| |cellular senescence| |cellular response to virus| |positive regulation of myotube differentiation| |positive regulation of cardiac muscle tissue growth| |lipopolysaccharide-mediated signaling pathway| |positive regulation of interleukin-12 production| |positive regulation of protein import into nucleus| |regulation of macrophage migration| |positive regulation of heart growth| |positive regulation of glucose import| |positive regulation of protein import| |cellular response to vascular endothelial growth factor stimulus| |regulation of cytokine production involved in inflammatory response| |regulation of cardiac muscle cell proliferation| |regulation of cyclase activity| |regulation of granulocyte chemotaxis| |mRNA stabilization| |positive regulation of glucose transmembrane transport| |osteoclast differentiation| |positive regulation of cardiac muscle tissue development| |regulation of mononuclear cell migration| |regulation of erythrocyte differentiation| |positive regulation of organ growth| |RNA stabilization| |negative regulation of mRNA catabolic process| |regulation of myoblast differentiation| |regulation of interleukin-12 production| |positive regulation of cytokine production involved in immune response| |regulation of glucose import| |regulation of protein import into nucleus| |positive regulation of blood vessel endothelial cell migration| |regulation of myotube differentiation| |regulation of cardiac muscle tissue growth| |positive regulation of striated muscle cell differentiation| |regulation of protein import| |negative regulation of RNA catabolic process| |positive regulation of fat cell differentiation| |positive regulation of nucleocytoplasmic transport| |regulation of heart growth| |cell aging| |vascular endothelial growth factor receptor signaling pathway| |positive regulation of muscle organ development| |positive regulation of striated muscle tissue development| |cellular response to ionizing radiation| |positive regulation of muscle tissue development| |regulation of glucose transmembrane transport| |positive regulation of protein localization to nucleus| |fatty acid oxidation| |lipid oxidation| |negative regulation of mRNA metabolic process| |regulation of cardiac muscle tissue development| |chondrocyte differentiation| |regulation of cytokine production involved in immune response| |protein phosphatase binding| |positive regulation of muscle cell differentiation| |positive regulation of leukocyte chemotaxis| |regulation of blood vessel endothelial cell migration| |positive regulation of myeloid cell differentiation| |regulation of organ growth| |positive regulation of reactive oxygen species metabolic process| |positive regulation of production of molecular mediator of immune response| |positive regulation of endothelial cell migration| |regulation of striated muscle cell differentiation| |signal transduction in response to DNA damage| |stress-activated MAPK cascade| |regulation of nucleocytoplasmic transport| |myeloid leukocyte differentiation| |regulation of leukocyte chemotaxis| |glucose metabolic process| |secretory granule lumen| |regulation of protein localization to nucleus| |spindle pole| |regulation of fat cell differentiation| |skeletal muscle tissue development| |ficolin-1-rich granule lumen| |positive regulation of leukocyte migration| |DNA damage checkpoint| |regulation of striated muscle tissue development| |skeletal muscle organ development| |regulation of muscle tissue development| |regulation of muscle organ development| |positive regulation of chemotaxis| |positive regulation of cytokine secretion| |regulation of production of molecular mediator of immune response| |positive regulation of epithelial cell migration| |stress-activated protein kinase signaling cascade| |DNA integrity checkpoint| |response to ionizing radiation| |placenta development| |regulation of muscle cell differentiation| |positive regulation of intracellular protein transport| |activation of MAPK activity| |hexose metabolic process| |regulation of endothelial cell migration| |positive regulation of developmental growth| |cartilage development| |peptidyl-serine phosphorylation| |negative regulation of canonical Wnt signaling pathway| |cellular response to radiation| |regulation of mRNA stability| |regulation of reactive oxygen species metabolic process| |regulation of signal transduction by p53 class mediator| |regulation of RNA stability| |cellular response to lipopolysaccharide| |positive regulation of hemopoiesis| |regulation of ossification| |positive regulation of peptidase activity| |cellular response to molecule of bacterial origin| |cell cycle checkpoint| |regulation of leukocyte migration| |peptidyl-serine modification| |transmembrane receptor protein serine/threonine kinase signaling pathway| |monosaccharide metabolic process| |striated muscle cell differentiation| |regulation of mRNA catabolic process| |lipid modification| |positive regulation of transmembrane transport| |regulation of cytokine secretion| |positive regulation of intracellular transport| |negative regulation of Wnt signaling pathway| |regulation of chemotaxis| |response to mechanical stimulus| |cellular response to biotic stimulus| |regulation of synapse organization| |positive regulation of immune effector process| |regulation of epithelial cell migration| |myeloid cell differentiation| |connective tissue development| |regulation of myeloid cell differentiation| |regulation of synapse structure or activity| |regulation of intracellular protein transport| |skeletal system morphogenesis| |cellular response to tumor necrosis factor| |muscle cell differentiation| |Ras protein signal transduction| |negative regulation of cellular catabolic process| |positive regulation of growth| |positive regulation of MAP kinase activity| |response to tumor necrosis factor| |positive regulation of protein secretion| |aging| |response to virus| |regulation of canonical Wnt signaling pathway| |striated muscle tissue development| |positive regulation of peptide secretion| |muscle organ development| |muscle tissue development| |negative regulation of catabolic process| |cellular response to abiotic stimulus| |cellular response to environmental stimulus| |response to lipopolysaccharide| |angiogenesis| |small GTPase mediated signal transduction| |fatty acid metabolic process| |positive regulation of cellular protein localization| |response to molecule of bacterial origin| |activation of protein kinase activity| |regulation of mRNA metabolic process| |regulation of developmental growth| |leukocyte differentiation| |regulation of inflammatory response| |positive regulation of protein serine/threonine kinase activity| |regulation of MAP kinase activity| |enzyme binding| |glutamatergic synapse| |regulation of intracellular transport| |positive regulation of proteolysis| |regulation of Wnt signaling pathway| |protein serine/threonine kinase activity| |MAPK cascade| |signal transduction by protein phosphorylation| |regulation of cell-cell adhesion| |nuclear speck| |positive regulation of secretion by cell| |blood vessel morphogenesis| |reproductive structure development| |positive regulation of protein transport| |regulation of DNA-binding transcription factor activity| |reproductive system development| |positive regulation of secretion| |response to radiation| |regulation of peptidase activity| |positive regulation of cytokine production| |regulation of hemopoiesis| |positive regulation of establishment of protein localization| |regulation of protein secretion| |regulation of immune effector process| |response to peptide| |carbohydrate metabolic process| |muscle structure development| |blood vessel development| |neutrophil degranulation| |neutrophil activation involved in immune response| |skeletal system development| |regulation of peptide secretion| |neutrophil mediated immunity| |cellular response to growth factor stimulus| |positive regulation of cell migration| |neutrophil activation| |granulocyte activation| |transmembrane receptor protein tyrosine kinase signaling pathway| |vasculature development| |leukocyte degranulation| |regulation of protein serine/threonine kinase activity| |myeloid leukocyte mediated immunity| |cardiovascular system development| |cellular response to lipid| |myeloid cell activation involved in immune response| |positive regulation of cell motility| |posttranscriptional regulation of gene expression| |monocarboxylic acid metabolic process| |response to growth factor| |positive regulation of protein kinase activity| |positive regulation of cellular component movement| |regulation of cellular protein localization| |positive regulation of MAPK cascade| |chemotaxis| |positive regulation of locomotion| |taxis| |hemopoiesis| |regulation of transmembrane transport| |negative regulation of cell cycle| |positive regulation of kinase activity| |myeloid leukocyte activation| |positive regulation of response to external stimulus| |hematopoietic or lymphoid organ development| |leukocyte activation involved in immune response| |cell activation involved in immune response| |immune system development| |tube morphogenesis| |positive regulation of transferase activity| |developmental process involved in reproduction| |regulation of growth| |regulation of cell adhesion| |response to bacterium| |regulation of cytokine production| |regulated exocytosis| |regulation of protein transport| |enzyme linked receptor protein signaling pathway| |cell morphogenesis| |regulation of proteolysis| |regulation of peptide transport| |regulation of establishment of protein localization| |regulation of secretion by cell| |regulation of MAPK cascade| |regulation of defense response| |leukocyte mediated immunity| |positive regulation of hydrolase activity| |cellular response to DNA damage stimulus| |exocytosis| |regulation of protein kinase activity| |regulation of secretion| |cellular component morphogenesis| |regulation of cellular catabolic process| |tube development| |regulation of cell migration| |response to lipid| |positive regulation of immune response| |circulatory system development| |regulation of kinase activity| |peptidyl-amino acid modification| |anatomical structure formation involved in morphogenesis| |carboxylic acid metabolic process| |regulation of cell motility| |positive regulation of cell population proliferation| |regulation of cellular localization| |apoptotic process| |leukocyte activation| |cellular lipid metabolic process| |animal organ morphogenesis| |oxidation-reduction process| |positive regulation of cell differentiation| |protein phosphorylation| |regulation of transferase activity| |regulation of locomotion| |positive regulation of transport| |regulation of catabolic process| |regulation of cellular component movement| |response to organonitrogen compound| |oxoacid metabolic process| |secretion by cell| |cellular response to cytokine stimulus| |positive regulation of protein phosphorylation| |positive regulation of intracellular signal transduction| |response to drug| |organic acid metabolic process| |regulation of protein localization| |export from cell| |programmed cell death| |cellular response to oxygen-containing compound| |positive regulation of phosphorylation| |regulation of anatomical structure morphogenesis| |cell activation| |response to nitrogen compound| |immune effector process| |cell death| |regulation of response to external stimulus| |response to cytokine| |secretion| |positive regulation of phosphorus metabolic process| |positive regulation of phosphate metabolic process| |positive regulation of immune system process| |regulation of immune response| |response to abiotic stimulus| |regulation of cell cycle| |positive regulation of cellular component organization| |lipid metabolic process| |positive regulation of transcription by RNA polymerase II| |positive regulation of protein modification process| |mitochondrion| |negative regulation of signal transduction| |regulation of hydrolase activity| |phosphorylation| |response to other organism| |response to external biotic stimulus| |locomotion| |response to biotic stimulus| |negative regulation of RNA metabolic process| |negative regulation of cell communication| |negative regulation of signaling| |positive regulation of developmental process| |reproductive process| |reproduction| |positive regulation of catalytic activity| |negative regulation of nucleobase-containing compound metabolic process| |regulation of protein phosphorylation| |regulation of response to stress| |ATP binding| |positive regulation of transcription, DNA-templated| |response to oxygen-containing compound| |regulation of phosphorylation| |positive regulation of cellular protein metabolic process| |regulation of cell population proliferation| |negative regulation of response to stimulus| |positive regulation of nucleic acid-templated transcription| |positive regulation of RNA biosynthetic process| |regulation of immune system process| |positive regulation of signal transduction| |intracellular signal transduction| |cellular response to stress| |positive regulation of protein metabolic process| |positive regulation of RNA metabolic process| |positive regulation of multicellular organismal process| |small molecule metabolic process| |tissue development| |positive regulation of molecular function| |regulation of phosphate metabolic process| |regulation of phosphorus metabolic process| |regulation of cell differentiation| |positive regulation of cell communication| |positive regulation of signaling| |regulation of intracellular signal transduction| |regulation of protein modification process| |regulation of transport| |immune response| |positive regulation of nucleobase-containing compound metabolic process| |positive regulation of macromolecule biosynthetic process| |extracellular region| |vesicle-mediated transport| |positive regulation of cellular biosynthetic process| |positive regulation of gene expression| |positive regulation of biosynthetic process| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.97| |[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.37| |[[:results:exp187|proTAME 5μM R04 exp187]]|-2.36| |[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.24| |[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.23| |[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.21| |[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.19| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.12| |[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.1| |[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.07| |[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.04| |[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.98| |[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.97| |[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.94| |[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.91| |[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.81| |[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.78| |[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.76| |[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.7| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.72| |[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.85| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.96| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2| |[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.08| |[[:results:exp19|Etoposide 1μM R00 exp19]]|2.66| |[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.57| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:c:ccdc101|CCDC101]]|0.562| |[[:human genes:t:thoc6|THOC6]]|0.551| |[[:human genes:r:rptor|RPTOR]]|0.543| |[[:human genes:g:gtf3c2|GTF3C2]]|0.543| |[[:human genes:r:rnmt|RNMT]]|0.538| |[[:human genes:a:aars|AARS]]|0.537| |[[:human genes:a:alg5|ALG5]]|0.536| |[[:human genes:s:srp68|SRP68]]|0.519| |[[:human genes:g:gnb1l|GNB1L]]|0.515| |[[:human genes:g:gmppb|GMPPB]]|0.51| |[[:human genes:p:pmm2|PMM2]]|0.509| |[[:human genes:w:wdr24|WDR24]]|0.503| |[[:human genes:t:tti2|TTI2]]|0.498| |[[:human genes:o:otud5|OTUD5]]|0.497| |[[:human genes:m:med16|MED16]]|0.495| |[[:human genes:m:mllt1|MLLT1]]|0.489| |[[:human genes:t:tti1|TTI1]]|0.486| |[[:human genes:e:eny2|ENY2]]|0.481| |[[:human genes:c:cbfb|CBFB]]|0.478| |[[:human genes:t:telo2|TELO2]]|0.477| |[[:human genes:a:arih1|ARIH1]]|0.469| |[[:human genes:c:csnk2b|CSNK2B]]|0.469| |[[:human genes:d:dpagt1|DPAGT1]]|0.468| |[[:human genes:r:rtcb|RTCB]]|0.467| |[[:human genes:m:mtor|MTOR]]|0.467| |[[:human genes:a:atf7ip|ATF7IP]]|0.463| |[[:human genes:m:med23|MED23]]|0.462| |[[:human genes:l:lamtor4|LAMTOR4]]|0.462| |[[:human genes:c:cbx3|CBX3]]|0.455| |[[:human genes:t:thg1l|THG1L]]|0.455| |[[:human genes:n:nars|NARS]]|0.451| |[[:human genes:d:dnajc3|DNAJC3]]|0.451| |[[:human genes:t:tle4|TLE4]]|0.451| |[[:human genes:e:elac2|ELAC2]]|0.451| |[[:human genes:t:trmt5|TRMT5]]|0.449| |[[:human genes:a:alg1|ALG1]]|0.448| |[[:human genes:l:lamtor5|LAMTOR5]]|0.447| |[[:human genes:c:cct7|CCT7]]|0.447| |[[:human genes:t:taf5l|TAF5L]]|0.446| |[[:human genes:a:atp5j|ATP5J]]|0.446| |[[:human genes:n:nxt1|NXT1]]|0.445| |[[:human genes:h:hars|HARS]]|0.445| |[[:human genes:l:lsmd1|LSMD1]]|0.44| |[[:human genes:m:map3k4|MAP3K4]]|0.439| |[[:human genes:e:eif4e|EIF4E]]|0.438| |[[:human genes:x:xpot|XPOT]]|0.437| |[[:human genes:t:tmem41b|TMEM41B]]|0.435| |[[:human genes:r:rpe|RPE]]|0.432| |[[:human genes:d:dohh|DOHH]]|0.432| |[[:human genes:t:triap1|TRIAP1]]|0.432| |[[:human genes:n:nupl2|NUPL2]]|0.432| |[[:human genes:u:uhrf1|UHRF1]]|0.43| |[[:human genes:a:adsl|ADSL]]|0.429| |[[:human genes:p:pax5|PAX5]]|0.427| |[[:human genes:d:dpf2|DPF2]]|0.426| |[[:human genes:u:ube2g1|UBE2G1]]|0.425| |[[:human genes:s:ssbp2|SSBP2]]|0.425| |[[:human genes:u:ube2l3|UBE2L3]]|0.425| |[[:human genes:m:med4|MED4]]|0.423| |[[:human genes:t:tbp|TBP]]|0.422| |[[:human genes:m:max|MAX]]|0.422| |[[:human genes:s:srp72|SRP72]]|0.42| |[[:human genes:a:alg13|ALG13]]|0.417| |[[:human genes:d:derl2|DERL2]]|0.417| |[[:human genes:a:alg6|ALG6]]|0.416| |[[:human genes:v:vrk1|VRK1]]|0.415| |[[:human genes:l:lsm11|LSM11]]|0.414| |[[:human genes:u:uba3|UBA3]]|0.413| |[[:human genes:b:b3gnt2|B3GNT2]]|0.413| |[[:human genes:m:meaf6|MEAF6]]|0.412| |[[:human genes:g:gtf3c3|GTF3C3]]|0.411| |[[:human genes:y:yars|YARS]]|0.409| |[[:human genes:p:polr3h|POLR3H]]|0.406| |[[:human genes:p:pelo|PELO]]|0.405| |[[:human genes:g:gfpt1|GFPT1]]|0.404| |[[:human genes:g:gtf3c4|GTF3C4]]|0.404| |[[:human genes:o:osgep|OSGEP]]|0.403| |[[:human genes:z:zc3h11a|ZC3H11A]]|0.402| |[[:human genes:t:tceb3|TCEB3]]|0.402| |[[:human genes:n:naa20|NAA20]]|0.402| |[[:human genes:a:alg2|ALG2]]|0.402| |[[:human genes:t:tada1|TADA1]]|0.401| |[[:human genes:u:ube3a|UBE3A]]|0.401| |[[:human genes:s:supt7l|SUPT7L]]|0.4| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 4/726 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|0/28| |blood|0/28| |bone|0/25| |breast|0/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|0/13| |fibroblast|0/1| |gastric|0/15| |kidney|0/21| |liver|1/20| |lung|0/75| |lymphocyte|0/14| |ovary|0/26| |pancreas|0/24| |peripheral nervous system|0/16| |plasma cell|0/15| |prostate|0/1| |skin|0/24| |soft tissue|1/7| |thyroid|0/2| |upper aerodigestive|0/22| |urinary tract|0/29| |uterus|0/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 5214 * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='MAPK14 Expression in NALM6 Cells: 6.99'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2025/12/10 20:19by 127.0.0.1