GTF3C4

Gene Information

Official Symbol: GTF3C4
Official Name: general transcription factor IIIC subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 9329
UniProt: Q9UKN8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
ALG1	0.636
GTF3C2	0.626
THG1L	0.615
TRMT5	0.61
RNMT	0.601
DPAGT1	0.589
ATXN10	0.583
PMM2	0.581
ALG5	0.577
SRP14	0.575
RTCB	0.567
GTF3C6	0.557
TTI2	0.554
GTF3C3	0.553
GFPT1	0.551
GMPPB	0.55
RPTOR	0.546
RPP21	0.544
POLR3H	0.543
MED16	0.542
DOHH	0.532
PELO	0.529
GNB1L	0.522
DOLK	0.52
EXOC3	0.517
UAP1	0.517
ALG13	0.514
EXOC4	0.513
ALG6	0.511
TSEN54	0.51
CCDC101	0.505
CCDC115	0.5
TRIAP1	0.498
UBE2G2	0.498
NAE1	0.496
DAD1	0.494
TTI1	0.494
VEZT	0.493
UBA5	0.489
SSB	0.488
RFT1	0.488
DHPS	0.483
UTP23	0.481
PPP4C	0.481
SEC62	0.48
SEC63	0.478
CDIPT	0.478
UFSP2	0.477
PPA2	0.475
ALG14	0.473
PPCS	0.472
TELO2	0.471
FH	0.471
CBFB	0.471
KDSR	0.468
UBA3	0.468
MBTPS2	0.467
UHRF1	0.465
SRP72	0.462
TMED10	0.461
ALG2	0.459
TRNT1	0.458
ELP3	0.455
MED23	0.455
OSGEP	0.455
ADSL	0.454
BAP1	0.453
GTF3C5	0.453
ATP5B	0.452
RPE	0.452
WDR24	0.452
ROMO1	0.452
DR1	0.45
TRMT10A	0.45
AARS	0.45
TMEM41B	0.45
CTDNEP1	0.449
FEN1	0.449
EEF1E1	0.448
SRPRB	0.447
OTUD5	0.447
RAD1	0.447
TTC4	0.447
SRP68	0.447
PDAP1	0.445
CMTR1	0.444
RABGGTB	0.444
VMP1	0.443
DDX20	0.443
BUB3	0.441
ATP5O	0.441
DHRSX	0.44
DNAJC3	0.438
PIK3C3	0.437
MLLT1	0.436
ATP2A2	0.435
XPOT	0.432
TIMM22	0.432
TXNL4B	0.431
ZBTB11	0.431
C1orf27	0.431
WDR59	0.43
BRD9	0.43
ORAOV1	0.429
PGGT1B	0.428
PIK3R4	0.428
RBM14	0.427
LSM10	0.427
POLR3C	0.426
GEMIN5	0.426
PLAA	0.426
POLR3B	0.426
DDOST	0.426
HAUS8	0.425
LSMD1	0.424
LSM11	0.423
CHCHD4	0.423
HSPD1	0.422
TBCB	0.422
ELAC2	0.421
SRD5A3	0.419
ENY2	0.419
STT3A	0.418
GEMIN8	0.417
MTOR	0.417
PAM16	0.415
GEMIN6	0.414
SLC25A26	0.413
SEC61G	0.413
IRF2BP2	0.413
ATP5J	0.411
UFC1	0.411
UXT	0.41
EIF4E	0.41
WDR92	0.409
GTF3A	0.409
SDHA	0.409
RPN1	0.408
TEN1	0.408
UBE2J1	0.408
TAZ	0.407
PPP6C	0.407
MBTPS1	0.407
DDX1	0.407
TRIM28	0.407
TBCA	0.406
FNTA	0.406
TAF11	0.405
MAPK14	0.404
NBN	0.404
GTF2H3	0.404
ATRX	0.404
YARS	0.404
UBE2M	0.402
CRCP	0.401
SNAPC5	0.4

Global Fraction of Cell Lines Where Essential: 9/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	1/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1007
Expression level (log2 read counts): 6.8

Expression Distribution

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-2.07
BI-6727 0.04μM R03 exp98	1.76
BI-2536 0.02μM R03 exp96	1.96
GSK461364A 0.1μM R03 exp126	2.46

zf-TFIIIC
TFIIIC delta

transcription factor TFIIIC complex
5S class rRNA transcription by RNA polymerase III
tRNA transcription by RNA polymerase III
tRNA transcription
transcription initiation from RNA polymerase III promoter
rRNA transcription
transcription by RNA polymerase III
enzyme activator activity
histone acetyltransferase activity
ncRNA transcription
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
protein acylation
DNA-templated transcription, initiation
peptidyl-lysine modification
histone modification
covalent chromatin modification
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
peptidyl-amino acid modification
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
positive regulation of catalytic activity
DNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
gene expression