PLAA

Gene Information

Official Symbol: PLAA
Official Name: phospholipase A2 activating protein
Aliases and Previous Symbols: N/A
Entrez ID: 9373
UniProt: Q9Y263
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). {ECO:0000250|UniProtKB:P27612, ECO:0000269|PubMed:18291623, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-5083 0.4μM R08 exp468	-4.48
Golgicide-A 4μM R03 exp122	-2.76
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.24
FK-506 5μM R07 exp358	-2.15
CoCl2 18μM R07 exp346	-2.08
SB203580 25μM R03 exp149	-2.01
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.78
Nicotinamide Riboside 100μM R03 exp139	-1.77
Nicotine 3000μM R08 exp510	-1.75
2-Deoxy-D-glucose 800μM R05 exp214	1.72
LLY-283 2.6μM R06 exp290	1.74
Deferoxamine 11μM R07 exp350	1.78
Wortmannin 5μM R00 exp38	1.81
Cytochalasin-B 5μM R07 exp349	1.83
Thimerosal 0.85μM R08 exp529	1.92
Citral 75μM R06 exp275	1.97
Nocodazole 0.1μM R03 exp94	2.03
Pyridostatin 4μM R05 exp240	2.03
UM0129480 7μM R02 exp85	2.03
Artemisinin 50μM R08 exp450	2.1
LY2090314 0.003μM R08 exp499	2.1
Etoposide 10μM R00 exp20	2.12
Dinaciclib 0.007μM R07 exp355	2.22
JQ1 0.8μM R08 exp435	2.26
LY2090314 0.003μM R08 exp500 no dilution day6	2.31
THZ1 0.06μM R08 exp531	2.33
Centrinone 0.5μM R07 exp343	2.35
DABN racemic mixture R03 exp93	2.39
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.42
GSK-J4 1.5μM R08 exp441	2.42
AICAR 240μM R05 exp211	2.48
Atovaquone 15μM R08 exp451	2.5
Rotenone 2μM R00 exp33	2.52
HMS-I1 10μM R06 exp256	2.73
AICAR 240μM R03 exp116	2.98
RO-3307 4.7μM R02 exp80	3.04
MLN-4924 2μM R00 exp22	3.17
CI-1040 9.5μM R08 exp472	3.19
Etoposide 0.1μM R05 exp198	3.3
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.32
MS023 2μM R03 exp134	3.33
Pimelic-diphenylamide-106 5μM R00 exp28	3.38
Olaparib 4μM R08 exp512	3.41
GSK626616 14μM R08 exp485	3.62
Ethanol 0.01 R05 exp234	3.63
Dorsomorphin 5μM R07 exp357	3.75
Hippuristanol 0.12μM R08 exp488	3.85
Tanespimycin 14μM R08 exp527	3.93
Mitomycin-C 0.06μM R08 exp503	3.94
Aphidicolin 0.4μM R08 exp440	4.1
Rotenone 20μM R00 exp34	4.12
Staurosporine 0.02μM R08 exp524	4.13
PU-H71 1μM R08 exp515	4.19
Bleomycin 5μM R08 exp459	4.4
Benzoate 20000μM R08 exp456	4.69
Doxorubicin 0.02μM R08 exp478	4.73
MS023 7μM R03 exp135	5.6
5-Fluorouracil 20μM R00 exp2	5.79
Actinomycin-D 0.001μM R00 exp3	6.12
Etoposide 1μM R00 exp19	6.13
Etoposide 0.3μM R05 exp199	6.92

Gene	Correlation
BAK1	0.759
APAF1	0.756
UBQLN1	0.741
CASP9	0.718
FAF2	0.693
MARCH5	0.688
VDAC2	0.674
DOHH	0.665
RAD23B	0.661
DIABLO	0.634
HARS	0.629
HSPD1	0.617
CYCS	0.609
HCCS	0.606
GFPT1	0.59
ENY2	0.586
RPTOR	0.581
THG1L	0.58
TRIAP1	0.577
UBE2K	0.577
SERF2	0.571
UBE2G2	0.553
ROMO1	0.549
KDSR	0.542
UAP1	0.539
ATAD1	0.537
MTOR	0.535
GMPPB	0.53
GABPA	0.529
MEAF6	0.528
MFN1	0.522
RTCB	0.516
BAP1	0.514
RNMT	0.511
ATP5J	0.51
PMM2	0.508
ALG1	0.503
STAU1	0.503
NSD1	0.499
OPA1	0.49
WDR59	0.485
PPP2R3C	0.484
NXT1	0.483
ZZZ3	0.482
WDR24	0.482
TRIM28	0.482
TAZ	0.48
NAE1	0.477
METAP2	0.476
UBA3	0.476
CTDNEP1	0.474
DPAGT1	0.469
PELO	0.466
SEC63	0.465
ATP5I	0.465
PPP5C	0.463
CRLS1	0.455
GTF3C3	0.454
CSNK2B	0.454
TIMM13	0.452
SRP14	0.45
KCTD5	0.448
PAM16	0.446
TAMM41	0.444
ATP5O	0.444
DHPS	0.443
CCT7	0.442
GTF3A	0.441
NUPL2	0.438
ALG2	0.438
RPE	0.438
CBFB	0.438
MLST8	0.437
VHL	0.435
RPN1	0.432
ELF2	0.432
SLC25A26	0.431
PPA2	0.43
VEZT	0.429
EXOC4	0.427
ATP5B	0.427
PDPK1	0.426
DDHD2	0.426
GTF3C4	0.426
PISD	0.425
AUP1	0.424
ATP5A1	0.424
UBXN7	0.422
DR1	0.42
SEH1L	0.419
BPTF	0.419
EIF3F	0.418
GTF3C6	0.417
BRWD1	0.417
ENO1	0.416
SEC61G	0.415
UTP23	0.414
FECH	0.412
UBE2J1	0.411
VMP1	0.41
ATP2A2	0.409
DAD1	0.408
TAF4	0.407
PHB	0.406
ATXN10	0.406
EIF4E	0.405
ORAOV1	0.404
TMED10	0.403
TMEM41B	0.401

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15979
Expression level (log2 read counts): 5.48

Expression Distribution

PUL
WD40
PFU

phospholipase A2 activator activity
negative regulation of protein K63-linked ubiquitination
positive regulation of phospholipase A2 activity
ubiquitin recycling
negative regulation of protein polyubiquitination
positive regulation of synaptic vesicle recycling
regulation of protein K63-linked ubiquitination
regulation of phospholipase A2 activity
positive regulation of neuron migration
regulation of protein polyubiquitination
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
positive regulation of dendrite extension
regulation of synaptic vesicle recycling
regulation of dendrite extension
prostaglandin metabolic process
prostanoid metabolic process
regulation of neuron migration
positive regulation of phospholipase activity
regulation of phospholipase activity
positive regulation of lipase activity
negative regulation of protein ubiquitination
ubiquitin binding
negative regulation of protein modification by small protein conjugation or removal
regulation of lipase activity
unsaturated fatty acid metabolic process
icosanoid metabolic process
regulation of synaptic vesicle cycle
macroautophagy
positive regulation of cell growth
fatty acid derivative metabolic process
positive regulation of developmental growth
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
regulation of protein ubiquitination
cellular response to biotic stimulus
regulation of protein modification by small protein conjugation or removal
positive regulation of growth
process utilizing autophagic mechanism
autophagy
synapse