DDHD2

Entrez Summary: This gene encodes a phospholipase enzyme containing sterile-alpha-motif (SAM), WWE, and DDHD domains. This protein participates in membrane trafficking between the endoplastic reticulum and the Golgi body. Mutations in this gene can cause autosomal recessive spastic paraplegia 54. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
UniProt Summary: Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. {ECO:0000269|PubMed:11788596, ECO:0000269|PubMed:20932832, ECO:0000269|PubMed:22922100}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.37
IWR1 50μM R08 exp495	-2.08
FK-506 30μM R07 exp359	-2
MK2206 4μM R08 exp504	1.75
Rotenone 20μM R00 exp34	1.8
TRAIL 5ng/ml R00 exp35	1.9
Trimetrexate 0.03μM R08 exp535	1.92
Cannabidiol 13μM R08 exp465	1.96
Pimelic-diphenylamide-106 5μM R00 exp28	2.15
Doxorubicin 0.02μM R08 exp478	2.2
Olaparib 4μM R08 exp512	2.32
Hippuristanol 0.12μM R08 exp488	2.46
Aphidicolin 0.4μM R08 exp440	2.53
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.63
MS023 7μM R03 exp135	2.9
5-Fluorouracil 20μM R00 exp2	2.93

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mitochondrial fission
phospholipase activity
lipid droplet organization
triglyceride lipase activity
regulation of mitochondrial fission
triglyceride catabolic process
neutral lipid catabolic process
acylglycerol catabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
COPII-coated ER to Golgi transport vesicle
visual learning
glycerolipid catabolic process
visual behavior
triglyceride metabolic process
endoplasmic reticulum-Golgi intermediate compartment
associative learning
acylglycerol metabolic process
neutral lipid metabolic process
positive regulation of mitochondrion organization
learning
microtubule organizing center
regulation of mitochondrion organization
cellular lipid catabolic process
locomotory behavior
glycerophospholipid biosynthetic process
endoplasmic reticulum to Golgi vesicle-mediated transport
glycerolipid biosynthetic process
phospholipid biosynthetic process
learning or memory
cognition
lipid catabolic process
response to light stimulus
glycerophospholipid metabolic process
Golgi vesicle transport
phospholipid metabolic process
glycerolipid metabolic process
response to radiation
organophosphate biosynthetic process
behavior