MFN1

Entrez Summary: N/A
UniProt Summary: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-1.8
5-Azacytidine 2μM R07 exp330	1.72
Nicotinamide 2000μM R01 exp50	1.72
HMS-I1 10μM R06 exp256	1.78
Aphidicolin 0.4μM R08 exp440	1.89
MS023 7μM R03 exp135	1.91
PU-H71 1μM R08 exp515	2.12
Dinaciclib 0.007μM R07 exp355	2.15
5-Fluorouracil 20μM R00 exp2	2.29
Etoposide 0.3μM R05 exp199	2.29
Olaparib 4μM R08 exp512	2.31
Mitomycin-C 0.06μM R08 exp503	2.37
Pimelic-diphenylamide-106 5μM R00 exp28	2.4
Benzoate 20000μM R08 exp456	2.54
Etoposide 1μM R00 exp19	2.58
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.98
Hippuristanol 0.12μM R08 exp488	3.34
Actinomycin-D 0.001μM R00 exp3	3.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Dynamin N
Fzo mitofusin

outer mitochondrial membrane protein complex
mitochondrial membrane fusion
intrinsic component of mitochondrial outer membrane
mitochondrial fusion
integral component of mitochondrial outer membrane
GTP metabolic process
guanosine-containing compound metabolic process
mitochondrion localization
purine ribonucleoside triphosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
ribonucleoside metabolic process
organelle membrane fusion
nucleoside triphosphate metabolic process
organelle fusion
nucleoside metabolic process
mitochondrial membrane organization
membrane fusion
glycosyl compound metabolic process
macroautophagy
mitochondrial outer membrane
autophagy
process utilizing autophagic mechanism
purine ribonucleotide metabolic process
ribonucleotide metabolic process
GTPase activity
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
GTP binding
mitochondrion organization
nucleotide metabolic process
nucleoside phosphate metabolic process
nucleobase-containing small molecule metabolic process
organelle localization
membrane organization
organophosphate metabolic process
carbohydrate derivative metabolic process