MFN1 [The Human Chemical-Genetic Interaction Map Project]

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======= MFN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MFN1
  * **<color #00a2e8>Official Name</color>**: mitofusin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55669|55669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWA4|Q8IWA4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MFN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MFN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynamin N|
|Fzo mitofusin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|outer mitochondrial membrane protein complex|
|mitochondrial membrane fusion|
|intrinsic component of mitochondrial outer membrane|
|mitochondrial fusion|
|integral component of mitochondrial outer membrane|
|GTP metabolic process|
|guanosine-containing compound metabolic process|
|mitochondrion localization|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|ribonucleoside metabolic process|
|organelle membrane fusion|
|nucleoside triphosphate metabolic process|
|organelle fusion|
|nucleoside metabolic process|
|mitochondrial membrane organization|
|membrane fusion|
|glycosyl compound metabolic process|
|macroautophagy|
|mitochondrial outer membrane|
|autophagy|
|process utilizing autophagic mechanism|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|GTPase activity|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|GTP binding|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|nucleobase-containing small molecule metabolic process|
|organelle localization|
|membrane organization|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|mitochondrion|
|small molecule metabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.8|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.72|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.78|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.89|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.91|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.12|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.15|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.29|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.29|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.31|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.37|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.4|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.54|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.58|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.34|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:apaf1|APAF1]]|0.576|
|[[:human genes:c:cycs|CYCS]]|0.573|
|[[:human genes:v:vdac2|VDAC2]]|0.567|
|[[:human genes:m:march5|MARCH5]]|0.558|
|[[:human genes:h:hars|HARS]]|0.557|
|[[:human genes:b:bak1|BAK1]]|0.554|
|[[:human genes:u:ubqln1|UBQLN1]]|0.553|
|[[:human genes:h:hccs|HCCS]]|0.54|
|[[:human genes:c:casp9|CASP9]]|0.537|
|[[:human genes:p:plaa|PLAA]]|0.522|
|[[:human genes:g:gabpa|GABPA]]|0.521|
|[[:human genes:u:ube2k|UBE2K]]|0.52|
|[[:human genes:d:diablo|DIABLO]]|0.513|
|[[:human genes:d:dohh|DOHH]]|0.511|
|[[:human genes:s:serf2|SERF2]]|0.51|
|[[:human genes:s:slmo2|SLMO2]]|0.505|
|[[:human genes:t:triap1|TRIAP1]]|0.502|
|[[:human genes:e:eny2|ENY2]]|0.495|
|[[:human genes:f:faf2|FAF2]]|0.464|
|[[:human genes:d:ddhd2|DDHD2]]|0.458|
|[[:human genes:h:hspd1|HSPD1]]|0.455|
|[[:human genes:a:atad1|ATAD1]]|0.451|
|[[:human genes:t:thg1l|THG1L]]|0.449|
|[[:human genes:o:opa1|OPA1]]|0.449|
|[[:human genes:g:gfpt1|GFPT1]]|0.447|
|[[:human genes:c:crls1|CRLS1]]|0.446|
|[[:human genes:r:romo1|ROMO1]]|0.442|
|[[:human genes:s:stau1|STAU1]]|0.438|
|[[:human genes:s:suv420h1|SUV420H1]]|0.43|
|[[:human genes:u:uap1|UAP1]]|0.43|
|[[:human genes:g:gtf3a|GTF3A]]|0.425|
|[[:human genes:p:pmm2|PMM2]]|0.419|
|[[:human genes:a:atp5j|ATP5J]]|0.416|
|[[:human genes:r:rptor|RPTOR]]|0.415|
|[[:human genes:m:meaf6|MEAF6]]|0.411|
|[[:human genes:a:atp5l|ATP5L]]|0.408|
|[[:human genes:n:nxt1|NXT1]]|0.404|
|[[:human genes:b:brwd1|BRWD1]]|0.404|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.404|
|[[:human genes:u:ube2m|UBE2M]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MFN1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>