GTF3A

Entrez Summary: N/A
UniProt Summary: Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
S-trityl-L-cysteine 0.5μM R05 exp243	-1.85
Nocodazole 0.1μM R03 exp94	1.72
AICAR 240μM R05 exp211	1.73
Bortezomib 0.05μM R00 exp7	1.76
Actinomycin-D 0.01μM R00 exp4	1.85
R-DABN 8μM R03 exp111	1.85
DABN racemic mixture R03 exp93	1.89
NN-Dimethylsphingosine 2.5μM R08 exp508	1.93
BI-6727 0.04μM R03 exp98	2.01
Benzoate 20000μM R08 exp456	2.03
Diepoxybutane 3μM R07 exp354	2.05
THZ531 0.225μM R08 exp444	2.21
MS023 7μM R03 exp135	2.29
GSK626616 14μM R08 exp485	2.33
Rucaparib 6.5μM R08 exp520	2.41
Etoposide 0.3μM R05 exp199	2.44
BI-2536 0.02μM R03 exp96	2.45
Deferoxamine 11μM R07 exp350	2.45
GSK461364A 0.1μM R03 exp126	2.47
MLN-4924 2μM R00 exp22	3.02
AICAR 240μM R03 exp116	3.17
5-Fluorouracil 20μM R00 exp2	3.23
Actinomycin-D 0.001μM R00 exp3	4.59

Global Fraction of Cell Lines Where Essential: 644/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	23/28
bone	24/26
breast	28/33
central nervous system	53/56
cervix	4/4
colorectal	12/17
esophagus	11/13
fibroblast	1/1
gastric	12/16
kidney	18/21
liver	19/20
lung	68/75
lymphocyte	14/16
ovary	22/26
pancreas	23/24
peripheral nervous system	13/16
plasma cell	15/15
prostate	0/1
skin	18/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	25/29
uterus	5/5

Expression Distribution

5S rRNA binding
rRNA transcription
transcription by RNA polymerase III
ribosomal large subunit biogenesis
ncRNA transcription
ribosome biogenesis
ribonucleoprotein complex biogenesis
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression