GTF3C3

Gene Information

Official Symbol: GTF3C3
Official Name: general transcription factor IIIC subunit 3
Aliases and Previous Symbols: N/A
Entrez ID: 9330
UniProt: Q9Y5Q9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	1.73
BI-6727 0.04μM R03 exp98	1.8
BI-2536 0.02μM R03 exp96	1.85
GSK461364A 0.1μM R03 exp126	1.92
Atovaquone 15μM R08 exp451	1.95
THZ1 0.06μM R08 exp531	1.95
Actinomycin-D 0.01μM R00 exp4	1.99
Nocodazole 0.1μM R03 exp94	2.1
Ammonium tetrathiomolybdate 10μM R08 exp448	2.16
MLN-4924 2μM R00 exp22	2.85
Actinomycin-D 0.001μM R00 exp3	3.36

Gene	Correlation
POLR3H	0.63
RTCB	0.63
THG1L	0.628
GMPPB	0.622
GNB1L	0.616
PMM2	0.613
UAP1	0.605
RPTOR	0.594
RNMT	0.59
DPAGT1	0.588
TTI2	0.586
ALG1	0.572
GFPT1	0.569
HSPD1	0.568
GTF3C6	0.568
EIF4E	0.566
GTF3C2	0.562
GTF3A	0.559
POLR3B	0.553
GTF3C4	0.553
ATXN10	0.553
MTOR	0.552
SRP14	0.551
HARS	0.549
ALG2	0.546
ALG13	0.544
TTI1	0.541
RPP21	0.54
DOHH	0.535
AARS	0.532
PPCS	0.531
GEMIN8	0.53
TRMT5	0.528
RPE	0.528
UXT	0.523
TRIAP1	0.521
TSEN54	0.52
DHPS	0.518
DR1	0.518
SNAPC5	0.517
NAE1	0.509
CCDC101	0.508
YARS	0.508
RABGGTB	0.507
HAUS8	0.506
TSEN34	0.505
EXOC4	0.504
SRP68	0.502
TELO2	0.501
TAZ	0.498
CRCP	0.497
ADSL	0.497
TRNT1	0.496
UBA3	0.495
TBCA	0.494
ENY2	0.493
CCT7	0.491
OSGEP	0.489
GEMIN5	0.488
NSMCE1	0.486
UHRF1	0.485
EPRS	0.484
WDR59	0.482
CEP57	0.481
PELO	0.481
TBP	0.479
NARS	0.479
GEMIN6	0.478
DDX20	0.476
MARS	0.475
DDX55	0.475
DAD1	0.474
GTF3C5	0.474
VEZT	0.472
RBMX2	0.471
CSNK2B	0.471
MED16	0.469
SRP72	0.468
SNF8	0.468
TBCB	0.467
ATP5J	0.465
EIF3F	0.464
TXNL4B	0.464
TAMM41	0.464
MEAF6	0.464
DHDDS	0.46
VRK1	0.459
RAD1	0.458
SRPRB	0.457
ORAOV1	0.457
THOC6	0.456
PLAA	0.454
HCCS	0.454
OTUD5	0.451
EXOC3	0.447
TMEM41B	0.446
TTC4	0.446
LSM11	0.442
PPP4C	0.442
TKT	0.44
ZNF259	0.439
ELAC2	0.438
DDOST	0.438
POLR3C	0.436
GEMIN7	0.436
CTC1	0.433
ALG14	0.431
RFT1	0.429
UTP23	0.429
TBCD	0.429
ABCF1	0.428
ZRSR2	0.428
PAX5	0.428
ATIC	0.427
ENO1	0.426
TEN1	0.426
OIP5	0.425
ALG5	0.424
APAF1	0.423
PAM16	0.423
URM1	0.419
WDR24	0.419
SLC35B1	0.418
SSB	0.418
TSEN2	0.418
UBA5	0.417
BAK1	0.417
PPP6C	0.415
SEC61G	0.415
TGS1	0.414
PDPK1	0.414
ROMO1	0.414
CRLS1	0.413
ATF7IP	0.412
ELP3	0.411
CBX3	0.411
MAPK14	0.411
NAF1	0.411
MLLT1	0.411
SLC25A26	0.411
C14orf166	0.411
NUP50	0.41
LAMTOR5	0.41
VMP1	0.41
SLC25A19	0.41
CHCHD4	0.41
DUSP12	0.409
GTF2A2	0.408
EEF1E1	0.408
CARS	0.407
RPN1	0.407
GPN2	0.407
ATP5B	0.404
ATRX	0.403
LAMTOR4	0.402
UBE2G2	0.402
TAF1A	0.402
SEC62	0.401
DPF2	0.401

Global Fraction of Cell Lines Where Essential: 5/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1517
Expression level (log2 read counts): 6.67

Expression Distribution

RNA polymerase III transcription regulator recruiting activity
RNA polymerase III general transcription initiation factor activity
transcription factor TFIIIC complex
5S class rRNA transcription by RNA polymerase III
tRNA transcription by RNA polymerase III
RNA polymerase III preinitiation complex assembly
tRNA transcription
transcription initiation from RNA polymerase III promoter
rRNA transcription
transcription preinitiation complex assembly
transcription by RNA polymerase III
ncRNA transcription
protein-DNA complex assembly
DNA-templated transcription, initiation
nuclear membrane
protein-DNA complex subunit organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression