NAF1

Entrez Summary: N/A
UniProt Summary: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 27/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	2/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Expression Distribution

box H/ACA snoRNP assembly
snoRNA guided rRNA pseudouridine synthesis
telomerase RNA stabilization
telomerase holoenzyme complex assembly
rRNA pseudouridine synthesis
small nucleolar ribonucleoprotein complex
small nucleolar ribonucleoprotein complex assembly
positive regulation of telomerase RNA localization to Cajal body
pseudouridine synthesis
regulation of telomerase RNA localization to Cajal body
telomerase RNA binding
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
rRNA modification
positive regulation of telomere maintenance via telomere lengthening
RNA stabilization
positive regulation of telomere maintenance
regulation of telomerase activity
regulation of telomere maintenance via telomerase
negative regulation of RNA catabolic process
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
regulation of telomere maintenance
regulation of DNA biosynthetic process
RNA modification
positive regulation of chromosome organization
regulation of RNA stability
positive regulation of DNA metabolic process
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
negative regulation of cellular catabolic process
ribosome biogenesis
negative regulation of catabolic process
regulation of chromosome organization
regulation of DNA metabolic process
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process