RPP21

Gene Information

Official Symbol: RPP21
Official Name: ribonuclease P/MRP subunit p21
Aliases and Previous Symbols: N/A
Entrez ID: 79897
UniProt: Q9H633
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 10μM R04 exp180	-2.96
UM0011500 5μM R05 exp245	-2.31
GSK343 3μM R03 exp124	-2.12
Ribavirin 10 to 15μM on day4 R04 exp160	-2.1
UNC1999 2μM R03 exp155	-1.89
UNC2400 2μM R03 exp156	-1.84
BH1 1μM R04 exp169	-1.8
ABT-702 0.1μM R06 exp260	-1.78
L-BMAA 500 to 750μM on day4 R04 exp185	-1.77
A-395 10μM R05 exp218	-1.74
Thalidomide 20μM R07 exp406	-1.74
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.7
GSK2606414 1μM R05 exp236	-1.7
42°C R08 exp539	1.78
CFI-400945 25μM R08 exp469	1.84
Artemisinin 50μM R08 exp450	1.9
Salinomycin 3.5μM R08 exp521	1.91
BVD-523 15μM R02 exp67	2.07
Nocodazole 0.1μM R03 exp94	2.07
THZ1 0.06μM R08 exp531	2.07
DABN racemic mixture R03 exp93	2.09
BI-6727 0.04μM R03 exp98	2.16
Cannabidiol 20μM R08 exp466	2.64
GSK461364A 0.1μM R03 exp126	2.75
BI-2536 0.02μM R03 exp96	2.76

Gene	Correlation
THG1L	0.704
ALG1	0.642
GMPPB	0.636
ADSL	0.627
PMM2	0.619
EXOC4	0.614
RTCB	0.613
OSGEP	0.61
TSEN54	0.603
UAP1	0.595
VEZT	0.595
GEMIN8	0.594
DPAGT1	0.594
GNB1L	0.588
RNMT	0.587
GEMIN6	0.586
NAE1	0.579
DDX20	0.577
GFPT1	0.574
UTP23	0.573
TEN1	0.565
UHRF1	0.56
ATXN10	0.56
GTF3C6	0.558
ELP2	0.555
SSB	0.554
URM1	0.552
GEMIN7	0.55
TELO2	0.546
RPTOR	0.546
RPIA	0.545
GTF3C4	0.544
GTF3C3	0.54
ALG13	0.54
TTI2	0.54
RFT1	0.539
ZRSR2	0.539
ELP3	0.536
MSTO1	0.535
DR1	0.531
PPCS	0.525
RPE	0.523
TBCB	0.522
FH	0.522
EPRS	0.52
CEP57	0.518
DOHH	0.518
TRMT5	0.517
MED16	0.517
TRIAP1	0.515
ALG2	0.514
YARS	0.514
RABGGTB	0.511
TPRKB	0.509
SRP14	0.508
PPP4C	0.508
EXOC3	0.508
PPP6C	0.507
DOLK	0.505
TTC4	0.504
GEMIN5	0.504
TSEN34	0.503
POLR3H	0.501
RAD1	0.501
ATP5O	0.5
GTF3C2	0.497
ERCC2	0.496
ATP5J	0.493
FNTA	0.493
DDX1	0.489
CTC1	0.488
RFK	0.486
PELO	0.484
SLC25A19	0.483
TAMM41	0.482
TRNT1	0.481
SNAPC5	0.48
CCDC101	0.48
UXT	0.48
KDM8	0.479
TTI1	0.479
LSM10	0.479
ALG6	0.477
FEN1	0.477
WDR92	0.476
ELAC2	0.474
ATP5B	0.474
TXNRD1	0.473
HSPD1	0.472
SRPK1	0.471
TXNL4B	0.469
DDX55	0.469
ELP6	0.467
EEF1E1	0.467
DHRSX	0.466
NAF1	0.466
TRMT61A	0.465
LSM11	0.464
NHP2	0.464
DHPS	0.462
C15orf41	0.462
VRK1	0.461
RNASEH2B	0.457
DCTN6	0.453
NSMCE1	0.452
ENY2	0.452
DDX39A	0.451
TPK1	0.451
TMEM41B	0.451
GPN2	0.45
ALG14	0.45
TIMM22	0.45
SPR	0.45
PDAP1	0.45
SUGT1	0.447
SGOL1	0.445
PPCDC	0.445
EFTUD1	0.445
PTAR1	0.444
EIF3F	0.444
UBE2G2	0.444
MED4	0.443
DAD1	0.443
FBXW7	0.442
ATP5A1	0.441
CTU1	0.439
PGGT1B	0.439
C1D	0.437
AARS	0.434
FNTB	0.433
DDOST	0.433
ATIC	0.433
TAF1A	0.433
HAUS8	0.433
SLC25A26	0.431
SNF8	0.431
MOCS3	0.43
CXorf56	0.43
CDIPT	0.43
METTL14	0.429
C14orf80	0.429
WDR82	0.428
NAA20	0.428
TRMT10A	0.427
PPP2R3C	0.425
ORAOV1	0.424
CBFB	0.424
TGS1	0.423
SEC61G	0.423
ATRX	0.422
CHCHD4	0.421
PGM3	0.42
ELP4	0.419
ZNHIT1	0.419
TBCA	0.418
WDR59	0.418
C14orf166	0.418
BAP1	0.418
SDHA	0.417
DICER1	0.417
UBA3	0.417
CSNK2B	0.416
PAXIP1	0.416
ALG5	0.415
KDSR	0.414
SEC62	0.413
ZBTB11	0.412
TMEM242	0.412
EIF4E	0.412
CRCP	0.412
BUB3	0.411
SPCS2	0.41
DPF2	0.41
CCT7	0.41
NARS	0.409
CIAO1	0.409
ATP5D	0.408
IPO9	0.407
EIF1AX	0.407
GTF2A2	0.407
THOC3	0.407
DNLZ	0.406
RAD50	0.406
SRD5A3	0.405
NBN	0.405
PAM16	0.404
SBDS	0.403
VHL	0.402
GTF3C5	0.4
BCS1L	0.4

Global Fraction of Cell Lines Where Essential: 729/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	25/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	0/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 122
Expression level (log2 read counts): 4.2

Expression Distribution

nucleolar ribonuclease P complex
ribonuclease P RNA binding
multimeric ribonuclease P complex
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
ncRNA metabolic process
RNA processing
response to drug
RNA metabolic process
gene expression