EIF1AX

Entrez Summary: N/A
UniProt Summary: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
EPZ-5676 30μM R05 exp233	-2.71
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.93
CR131-b 0.005μM R08 exp474	-1.84
CyclicAMP 200μM R08 exp475	-1.75
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.75
Apcin 50 to 100μM on day4 R04 exp176	-1.74
Rapamycin 1μM R00 exp29	-1.74
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.73
Ammonium tetrathiomolybdate 10μM R08 exp448	1.7
Rotenone 20μM R00 exp34	1.73
Epigallocatechin gallate 20μM R05 exp230	1.82
MLN-4924 2μM R00 exp22	1.83
Monensin 0.3μM R08 exp507	1.87
Nicotine 3000μM R08 exp510	1.89
Actinomycin-D 0.001μM R00 exp3	1.91
UMK57 1μM R01 exp59	1.92
Brefeldin A 0.02μM R00 exp8	1.93
ONC212 0.15μM R08 exp513	1.96
iCRT14 30μM R08 exp492	2.03
MS023 2μM R03 exp134	2.46
MS023 7μM R03 exp135	4.08

Global Fraction of Cell Lines Where Essential: 614/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	18/26
bone	21/26
breast	30/30
central nervous system	37/49
cervix	4/4
colorectal	17/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	15/18
liver	16/19
lung	65/72
lymphocyte	11/16
ovary	25/25
pancreas	20/22
peripheral nervous system	14/15
plasma cell	11/12
prostate	1/1
skin	19/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	23/28
uterus	5/5

Expression Distribution

translation factor activity, RNA binding
translation initiation factor activity
translational initiation
translation
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression