EIF1AX [The Human Chemical-Genetic Interaction Map Project]

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======= EIF1AX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF1AX
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 1A X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1964|1964]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47813|P47813]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF1AX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF1AX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF-1a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation factor activity, RNA binding|
|translation initiation factor activity|
|translational initiation|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.71|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.93|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.84|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.75|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.75|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.74|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.73|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.73|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.87|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.91|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.92|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.93|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.96|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.03|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.46|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.484|
|[[:human genes:u:uba5|UBA5]]|0.48|
|[[:human genes:z:zrsr2|ZRSR2]]|0.464|
|[[:human genes:d:dohh|DOHH]]|0.456|
|[[:human genes:t:tmem41b|TMEM41B]]|0.455|
|[[:human genes:e:eef1e1|EEF1E1]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.441|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.44|
|[[:human genes:p:pmm2|PMM2]]|0.439|
|[[:human genes:r:rtcb|RTCB]]|0.436|
|[[:human genes:t:trmt10a|TRMT10A]]|0.434|
|[[:human genes:d:dpagt1|DPAGT1]]|0.432|
|[[:human genes:e:elp2|ELP2]]|0.426|
|[[:human genes:b:bap1|BAP1]]|0.419|
|[[:human genes:s:sbds|SBDS]]|0.418|
|[[:human genes:c:c1orf27|C1orf27]]|0.417|
|[[:human genes:i:itpa|ITPA]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.41|
|[[:human genes:r:rpp21|RPP21]]|0.407|
|[[:human genes:e:eif1|EIF1]]|0.406|
|[[:human genes:d:dolk|DOLK]]|0.405|
|[[:human genes:e:eftud1|EFTUD1]]|0.403|
|[[:human genes:s:sec61g|SEC61G]]|0.401|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 614/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|18/26|
|bone|21/26|
|breast|30/30|
|central nervous system|37/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|15/18|
|liver|16/19|
|lung|65/72|
|lymphocyte|11/16|
|ovary|25/25|
|pancreas|20/22|
|peripheral nervous system|14/15|
|plasma cell|11/12|
|prostate|1/1|
|skin|19/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|23/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18186
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF1AX Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>