RNASEH2B

Gene Information

Official Symbol: RNASEH2B
Official Name: ribonuclease H2 subunit B
Aliases and Previous Symbols: N/A
Entrez ID: 79621
UniProt: Q5TBB1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].
UniProt Summary: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Resveratrol 16μM R03 exp147	-3.08
MK-1775 0.32μM R02 exp75	-2.68
Calcipotriol 5μM R08 exp464	-2.37
Olaparib 4μM R08 exp512	-2.33
Rucaparib 6.5μM R08 exp520	-2.02
THZ531 0.11μM R07 exp409	-1.99
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.91
CVT-10216 0.1μM R06 exp278	-1.75
Doxycycline 10μM R00 exp18	-1.73
Talazoparib 0.006μM R06 exp299	-1.7
Salinomycin 3.5μM R08 exp521	1.72
BI-2536 0.0042μM R03 exp95	1.87

Gene	Correlation
RNASEH2A	0.52
RABGGTB	0.502
ITPA	0.484
SPR	0.464
RPP21	0.457
PPP4C	0.431
ELP2	0.425
MCM9	0.417
KPNA4	0.416
EXOC4	0.41
TSEN54	0.407
FTSJ1	0.406
MCM8	0.404
RNASEH2C	0.402

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3187
Expression level (log2 read counts): 6.77

Expression Distribution

ribonuclease H2 complex
regulation of DNA damage checkpoint
RNA-DNA hybrid ribonuclease activity
regulation of cell cycle checkpoint
positive regulation of fibroblast proliferation
regulation of fibroblast proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
regulation of response to DNA damage stimulus
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
ribonucleotide metabolic process
ribose phosphate metabolic process
nucleobase-containing compound catabolic process
in utero embryonic development
regulation of mitotic cell cycle phase transition
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
regulation of cell cycle phase transition
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
regulation of mitotic cell cycle
chordate embryonic development
embryo development ending in birth or egg hatching
regulation of cellular response to stress
regulation of cell cycle process
organophosphate metabolic process
cellular macromolecule catabolic process
positive regulation of cell population proliferation
embryo development
carbohydrate derivative metabolic process
macromolecule catabolic process
regulation of cell cycle
regulation of response to stress
regulation of cell population proliferation