TPRKB

Entrez Summary: N/A
UniProt Summary: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol F 50μM R08 exp457	-2.56
Nocodazole 0.02μM R00 exp23	-2.07
Rifampicin 30μM R08 exp430	-1.97
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.81
Cyclosporin-A 3μM R07 exp348	-1.8
Chloramphenicol 2μM R00 exp12	-1.79
Alpha-Amanitin 0.5μM R00 exp5	-1.78
BRD2 inhibitor II 20μM R07 exp341	-1.76
Metformin 100 to 150μM on day4 R04 exp170	-1.72
Wortmannin 0.5μM R00 exp37	-1.72

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA threonylcarbamoyladenosine modification
EKC/KEOPS complex
tRNA threonylcarbamoyladenosine metabolic process
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
protein kinase binding
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression