HAUS8

Entrez Summary: N/A
UniProt Summary: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.2
GSK2606414 1μM R05 exp236	-2.19
A-395N 10μM R05 exp219	-2.13
Rapamycin 10μM R00 exp30	-2.03
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.88
Calcium Ionophore 0.4μM R07 exp342	-1.87
Docetaxel 0.002μM R01 exp45	-1.83
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.77
Demecolcine 0.03μM R05 exp228	-1.75
THZ531 0.11μM R07 exp409	-1.73
Vinblastine 0.002μM R01 exp60	-1.71
UM0131023 0.05μM R05 exp248	-1.7
SB743921 0.001μM R05 exp244	1.81
Atovaquone 15μM R08 exp451	1.83
Tanespimycin 14μM R08 exp527	2.32

Global Fraction of Cell Lines Where Essential: 82/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	3/28
bone	2/26
breast	4/33
central nervous system	7/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	4/20
lung	8/75
lymphocyte	3/16
ovary	3/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	0/5

Expression Distribution

nuclear microtubule
HAUS complex
centrosome cycle
microtubule organizing center organization
ciliary basal body-plasma membrane docking
spindle assembly
spindle pole
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
spindle organization
organelle localization by membrane tethering
membrane docking
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
mitotic cell cycle phase transition
cell cycle phase transition
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
microtubule cytoskeleton organization
centrosome
cell division
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle
regulation of cell cycle process
organelle assembly
molecular function
cell cycle process
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
cell cycle