PPP2R3C
Gene Information
- Official Symbol: PPP2R3C
- Official Name: protein phosphatase 2 regulatory subunit B''gamma
- Aliases and Previous Symbols: N/A
- Entrez ID: 55012
- UniProt: Q969Q6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of antimicrobial humoral response |
| positive regulation of B cell differentiation |
| regulation of mitochondrial depolarization |
| B cell homeostasis |
| regulation of B cell differentiation |
| spleen development |
| T cell homeostasis |
| regulation of membrane depolarization |
| cortical cytoskeleton organization |
| lymphocyte homeostasis |
| leukocyte homeostasis |
| regulation of mitochondrial membrane potential |
| positive regulation of lymphocyte differentiation |
| spindle |
| regulation of humoral immune response |
| positive regulation of leukocyte differentiation |
| positive regulation of B cell activation |
| regulation of lymphocyte differentiation |
| positive regulation of hemopoiesis |
| homeostasis of number of cells |
| regulation of B cell activation |
| regulation of dephosphorylation |
| regulation of leukocyte differentiation |
| activation of protein kinase activity |
| positive regulation of lymphocyte activation |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of membrane potential |
| regulation of hemopoiesis |
| microtubule cytoskeleton organization |
| centrosome |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| positive regulation of transferase activity |
| microtubule-based process |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of kinase activity |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| cytoskeleton organization |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.67 |
| ENY2 | 0.578 |
| FGFR1OP | 0.578 |
| DOHH | 0.555 |
| SRP14 | 0.553 |
| ALG1 | 0.55 |
| RPTOR | 0.549 |
| THG1L | 0.548 |
| PMM2 | 0.545 |
| BAP1 | 0.543 |
| RNMT | 0.542 |
| APAF1 | 0.533 |
| UHRF1 | 0.533 |
| CSNK2B | 0.523 |
| TRIAP1 | 0.513 |
| DPAGT1 | 0.512 |
| GMPPB | 0.511 |
| GFPT1 | 0.509 |
| HSPD1 | 0.505 |
| MTOR | 0.504 |
| WDR24 | 0.5 |
| UBE2G2 | 0.499 |
| PELO | 0.496 |
| UAP1 | 0.495 |
| UBE2K | 0.493 |
| ALG5 | 0.486 |
| PPA2 | 0.484 |
| PLAA | 0.484 |
| LSM10 | 0.475 |
| AARS | 0.474 |
| ID3 | 0.472 |
| ATXN10 | 0.472 |
| TSEN54 | 0.469 |
| FAF2 | 0.468 |
| CBFB | 0.467 |
| GTF3C6 | 0.465 |
| CASP9 | 0.464 |
| NARS | 0.464 |
| ALG6 | 0.462 |
| UBE2J1 | 0.461 |
| BAK1 | 0.46 |
| HCCS | 0.459 |
| RPE | 0.458 |
| RPIA | 0.458 |
| C14orf80 | 0.455 |
| HAUS8 | 0.454 |
| MED16 | 0.45 |
| CRLS1 | 0.448 |
| UBA5 | 0.448 |
| DNAJC3 | 0.448 |
| ALG13 | 0.447 |
| CCDC101 | 0.445 |
| RTCB | 0.444 |
| UTP23 | 0.442 |
| DNAJB11 | 0.439 |
| ENO1 | 0.438 |
| DR1 | 0.437 |
| DAD1 | 0.435 |
| DDX39A | 0.435 |
| CEP350 | 0.433 |
| SLC25A26 | 0.431 |
| DDHD2 | 0.43 |
| ROMO1 | 0.429 |
| NAT9 | 0.429 |
| TRIM28 | 0.429 |
| UBQLN1 | 0.426 |
| RPP21 | 0.425 |
| DHRSX | 0.424 |
| ORAOV1 | 0.424 |
| SSB | 0.424 |
| TRMT10A | 0.423 |
| NSD1 | 0.422 |
| ATP5J | 0.422 |
| TLE4 | 0.421 |
| WDR1 | 0.42 |
| TRMT5 | 0.419 |
| DIABLO | 0.418 |
| NAE1 | 0.417 |
| TTI2 | 0.416 |
| VHL | 0.416 |
| ADSL | 0.416 |
| DHPS | 0.416 |
| CTDNEP1 | 0.415 |
| PAM16 | 0.415 |
| OSGEP | 0.415 |
| OPA1 | 0.414 |
| TEN1 | 0.414 |
| KCTD5 | 0.414 |
| EPRS | 0.413 |
| TXNRD1 | 0.412 |
| MEAF6 | 0.412 |
| PPP6C | 0.412 |
| TMED10 | 0.411 |
| DDOST | 0.409 |
| SLC35B1 | 0.409 |
| VEZT | 0.407 |
| TAZ | 0.406 |
| PKM | 0.406 |
| TMEM41B | 0.406 |
| PDAP1 | 0.405 |
| SDHA | 0.404 |
| PHB | 0.404 |
| TBCA | 0.401 |
| DPF2 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 173/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 7/28 |
| blood | 11/28 |
| bone | 2/26 |
| breast | 10/33 |
| central nervous system | 5/56 |
| cervix | 3/4 |
| colorectal | 7/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 11/21 |
| liver | 5/20 |
| lung | 15/75 |
| lymphocyte | 3/16 |
| ovary | 6/26 |
| pancreas | 6/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 9/15 |
| prostate | 0/1 |
| skin | 9/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 6/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1285
- Expression level (log2 read counts): 5.29
Expression Distribution
PPP2R3C Expression in NALM6 Cells: 5.29
