PAM16

Gene Information

Official Symbol: PAM16
Official Name: presequence translocase associated motor 16
Aliases and Previous Symbols: N/A
Entrez ID: 51025
UniProt: Q9Y3D7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017].
UniProt Summary: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-1.91
Cycloheximide 0.02μM R00 exp14	-1.89
Thalidomide 20μM R07 exp406	-1.88
Actinomycin-D 0.001μM R00 exp3	1.74
Vinblastine 0.015μM R05 exp208	1.74
Nocodazole 0.1μM R03 exp94	1.79
GSK461364A 0.1μM R03 exp126	1.85
Doxorubicin 0.02μM R08 exp478	1.86
Rotenone 20μM R00 exp34	2.03
Vinblastine 0.2μM R03 exp108	2.18
Nocodazole 0.2μM R02 exp64	2.24
Etoposide 1μM R00 exp19	2.26
BI-6727 0.04μM R03 exp98	2.41
Etoposide 0.3μM R05 exp199	2.42

Gene	Correlation
TRIAP1	0.591
HARS	0.581
DPAGT1	0.576
RNMT	0.571
RPN1	0.561
PELO	0.556
HSPD1	0.553
RPTOR	0.551
PMM2	0.549
GMPPB	0.541
ALG2	0.535
ALG1	0.531
DAD1	0.52
VMP1	0.519
MEAF6	0.519
MED16	0.516
GFPT1	0.513
AARS	0.505
UAP1	0.505
TTI2	0.501
DDOST	0.5
HCCS	0.499
THG1L	0.497
CSNK2B	0.496
EPRS	0.493
TAMM41	0.492
RTCB	0.491
ORAOV1	0.48
NARS	0.479
NAE1	0.479
ALG5	0.478
PISD	0.477
SRP72	0.477
DHPS	0.476
EXOC4	0.476
EIF4E	0.474
CCDC101	0.474
GNB1L	0.469
DOHH	0.466
NSMCE1	0.465
RBM14	0.464
MTOR	0.462
GTF3A	0.461
CBFB	0.458
BAP1	0.455
SPCS2	0.454
ROMO1	0.451
TMEM41B	0.45
CASP9	0.448
PLAA	0.446
ENY2	0.446
HAUS8	0.446
ATXN10	0.445
APAF1	0.442
TSEN54	0.441
OSGEP	0.441
CRLS1	0.44
GTF3C2	0.439
WDR24	0.438
SRP68	0.436
CRCP	0.436
RPE	0.434
POLR3B	0.433
TGS1	0.432
TAZ	0.431
DDX20	0.43
GEMIN5	0.428
CARS	0.425
MLLT1	0.425
CYCS	0.424
GTF3C3	0.423
SRP14	0.423
TRNT1	0.422
NSD1	0.42
ALG13	0.42
TBCA	0.42
MARS	0.419
ADSL	0.418
TIMM13	0.418
SPCS3	0.417
PFN1	0.416
GTF3C4	0.415
PPP2R3C	0.415
TSEN2	0.415
UTP23	0.414
BUB3	0.413
TRMT5	0.413
ALG14	0.412
POLR3H	0.412
VRK1	0.411
TBCD	0.409
ZNF608	0.407
EXOC3	0.407
DCTN6	0.407
RPP21	0.404
HSPA9	0.402
YARS	0.402
SDHA	0.401
CDIPT	0.401
PHB	0.401
WARS	0.401

Global Fraction of Cell Lines Where Essential: 729/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1525
Expression level (log2 read counts): 4.02

Expression Distribution

negative regulation of apoptotic DNA fragmentation
negative regulation of DNA catabolic process
PAM complex, Tim23 associated import motor
TIM23 mitochondrial import inner membrane translocase complex
regulation of apoptotic DNA fragmentation
regulation of DNA catabolic process
extrinsic component of mitochondrial inner membrane
protein import into mitochondrial matrix
negative regulation of ATPase activity
negative regulation of release of cytochrome c from mitochondria
negative regulation of execution phase of apoptosis
protein transmembrane import into intracellular organelle
regulation of execution phase of apoptosis
regulation of release of cytochrome c from mitochondria
intracellular protein transmembrane transport
negative regulation of mitochondrion organization
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
regulation of ATPase activity
mitochondrial transmembrane transport
negative regulation of DNA metabolic process
protein import
regulation of mitochondrion organization
mitochondrial transport
negative regulation of apoptotic signaling pathway
negative regulation of cellular catabolic process
ossification
negative regulation of catabolic process
regulation of DNA metabolic process
protein targeting
mitochondrial matrix
negative regulation of organelle organization
regulation of apoptotic signaling pathway
establishment of protein localization to organelle
mitochondrion organization
negative regulation of hydrolase activity
protein-containing complex
negative regulation of cellular component organization