GNB1L [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: GNB1L
Official Name: G protein subunit beta 1 like
Aliases and Previous Symbols: N/A
Entrez ID: 54584
UniProt: Q9BYB4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.0125μM R03 exp97	-1.93
Pterostilbene 16μM R02 exp78	-1.87
ABT-702 5μM R06 exp261	-1.82
Nicotinate 1000μM R03 exp140	-1.82
Resveratrol 16μM R03 exp147	-1.78
Erlotinib 10μM R05 exp216	-1.76
Ethambutol 25μM R08 exp481	-1.76
Menadione 5μM R06 exp292	-1.74
WYE-354 6μM R02 exp90	-1.73
Cycloheximide 0.02μM R00 exp14	-1.71
Doxycycline 10μM R00 exp18	-1.7
IU1-C 25μM R04 exp183	-1.7
Temozolomide 200μM R04 exp189	-1.7
DABN racemic mixture R03 exp93	1.73
Atovaquone 15μM R08 exp451	1.86
BI-6727 0.04μM R03 exp98	2.04
Bleomycin 5μM R08 exp459	2.1
MLN-4924 2μM R00 exp22	2.27
Doxorubicin 0.02μM R08 exp478	2.38
BI-2536 0.02μM R03 exp96	2.39
THZ1 0.06μM R08 exp531	2.87
SNS-032 15μM R08 exp443	3.03

Gene	Correlation
TTI2	0.713
TTI1	0.679
TELO2	0.657
MED16	0.648
RNMT	0.64
RPTOR	0.64
GFPT1	0.629
CCDC101	0.622
RTCB	0.618
GTF3C3	0.616
PMM2	0.601
THG1L	0.597
GMPPB	0.596
DPAGT1	0.59
RPP21	0.588
ALG1	0.587
EXOC4	0.58
MLLT1	0.578
ALG13	0.578
GTF3C2	0.565
POLR3H	0.564
TSEN54	0.563
ALG2	0.56
DOHH	0.56
OSGEP	0.549
UAP1	0.546
MTOR	0.546
MED23	0.544
WDR24	0.538
PPP4C	0.537
UHRF1	0.536
AARS	0.536
CBFB	0.535
CSNK2B	0.529
ADSL	0.528
GTF3C6	0.527
RPN1	0.527
ZNF259	0.525
GTF3C4	0.522
SNAPC5	0.52
TRMT5	0.52
VMP1	0.519
NAE1	0.516
MAPK14	0.515
SRP14	0.512
DAD1	0.51
DDX20	0.509
POLR3B	0.508
SNF8	0.507
DDOST	0.505
CCT7	0.503
EIF4E	0.501
TSEN34	0.5
HSPD1	0.498
PELO	0.498
EPRS	0.498
YARS	0.493
TRNT1	0.493
FNTA	0.492
LSM11	0.491
ERCC2	0.491
RBM14	0.49
TAZ	0.49
DHPS	0.49
CRCP	0.486
HARS	0.48
UBE2G2	0.477
GEMIN8	0.476
ATXN10	0.476
VEZT	0.474
CDIPT	0.473
THOC6	0.473
GPN2	0.473
DR1	0.473
SEH1L	0.473
TAMM41	0.471
VHL	0.47
ATP5J	0.469
SRP72	0.469
PAM16	0.469
HAUS8	0.468
PPCS	0.468
UXT	0.466
TRIAP1	0.466
MARS	0.465
BUB3	0.464
TBCA	0.463
ATF7IP	0.463
PAX5	0.461
TLE4	0.459
ALG5	0.459
DHX29	0.458
OTUD5	0.458
RPE	0.457
LAMTOR4	0.457
TMEM41B	0.457
VRK1	0.453
ORAOV1	0.452
NARS	0.449
TBCB	0.449
WDR59	0.448
TSEN2	0.448
RAD1	0.447
LAMTOR5	0.447
DHDDS	0.444
DDX6	0.444
SPCS3	0.442
NSMCE1	0.441
GTF2A2	0.436
DDX1	0.434
SLC35B1	0.431
WDR82	0.43
ZBTB11	0.43
ALG14	0.427
ELAC2	0.427
XPO5	0.425
THOC3	0.425
C21orf59	0.422
SRP68	0.421
TEN1	0.42
TP53RK	0.42
DCTN5	0.418
BAP1	0.417
EXOC3	0.417
RFT1	0.417
WDR1	0.413
GTF3A	0.412
LSMD1	0.412
MAD2L1	0.409
ATP5B	0.408
MED25	0.407
ZRSR2	0.406
TADA1	0.406
WDR92	0.405
GEMIN6	0.405
MED4	0.404
MEAF6	0.403
TPRKB	0.403
EIF3F	0.401
DCTN6	0.401
UBA3	0.401
WARS	0.401
ATP5O	0.401
SLC25A19	0.4
ACTR10	0.4

Global Fraction of Cell Lines Where Essential: 287/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	11/28
blood	6/28
bone	12/26
breast	16/33
central nervous system	29/56
cervix	1/4
colorectal	3/17
esophagus	6/13
fibroblast	1/1
gastric	8/16
kidney	6/21
liver	8/20
lung	34/75
lymphocyte	1/16
ovary	11/26
pancreas	14/24
peripheral nervous system	5/16
plasma cell	3/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	2/2
upper aerodigestive	12/22
urinary tract	13/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 855
Expression level (log2 read counts): 3.0

Expression Distribution

Last modified: 2025/12/10 20:19
by 127.0.0.1