ATP5O

Gene Information

Official Symbol: ATP5PO
Official Name: ATP synthase peripheral stalk subunit OSCP
Aliases and Previous Symbols: N/A
Entrez ID: 539
UniProt: P48047
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-1.99
Bisphenol S 100μM R08 exp458	-1.88
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.86
Rifampicin 30μM R08 exp430	-1.75
Actinomycin-D 0.001μM R00 exp3	1.7
R-DABN 8μM R03 exp111	1.72
Nocodazole 0.1μM R03 exp94	1.73
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.76
Mubritinib 0.2μM R02 exp65	1.76
Trientine 500μM R08 exp534	1.77
Etoposide 0.3μM R05 exp199	1.82
Pimelic-diphenylamide-106 5μM R00 exp28	1.85
DABN racemic mixture R03 exp93	1.88
Aphidicolin 0.4μM R08 exp440	1.89
BI-D1870 3.15μM R02 exp66	1.9
Etoposide 1μM R00 exp19	1.94
HMS-I1 10μM R06 exp256	1.94
Senexin-A 25μM R07 exp400	1.98
UM131593 0.2μM R03 exp106	2.01
42°C R08 exp539	2.05
AICAR 240μM R05 exp211	2.06
Rotenone 0.07μM R08 exp431	2.08
Cannabidiol 20μM R08 exp466	2.09
Atovaquone 15μM R08 exp451	2.19
Citral 75μM R06 exp275	2.19
Vinblastine 0.2μM R03 exp108	2.2
Ammonium tetrathiomolybdate 10μM R08 exp448	2.25
Bleomycin 5μM R08 exp459	2.33
Doxorubicin 0.02μM R08 exp478	2.45
GSK461364A 0.1μM R03 exp126	2.52
BI-6727 0.04μM R03 exp98	2.53
Chloramphenicol 20μM R00 exp13	2.53
MS023 7μM R03 exp135	2.58
QNZ 0.01μM R08 exp439	2.58
Mitomycin-C 0.06μM R08 exp503	2.93
BI-2536 0.02μM R03 exp96	2.97
QNZ 0.01μM R05 exp241	2.99

Gene	Correlation
ATP5B	0.844
ATP5A1	0.764
ATP5D	0.73
ATP5C1	0.687
ATP5H	0.613
ATP5L	0.603
ATP5F1	0.596
ATP5J	0.589
TRIAP1	0.582
ATP5E	0.578
THG1L	0.575
UBE2G2	0.573
HSPD1	0.557
ATP5J2	0.542
BCS1L	0.54
PMM2	0.54
ATP5I	0.539
DPAGT1	0.532
FH	0.531
DOHH	0.525
ROMO1	0.523
GFPT1	0.519
SLC25A26	0.518
MBTPS2	0.509
TMEM242	0.509
UAP1	0.508
ADSL	0.504
RNMT	0.503
SUPV3L1	0.502
MRPL21	0.502
RPTOR	0.501
ALG1	0.501
RPP21	0.5
MED16	0.497
DOLK	0.491
GMPPB	0.485
TRNT1	0.483
ATXN10	0.481
HSD17B10	0.48
KDSR	0.479
ALG6	0.478
TAZ	0.477
ENY2	0.476
DARS2	0.476
DNAJC3	0.474
DHPS	0.473
SSB	0.473
EXOC4	0.472
PPA2	0.47
ALG5	0.469
ZRSR2	0.468
OPA1	0.467
UHRF1	0.464
CASP9	0.464
COX16	0.463
VEZT	0.462
C1orf27	0.461
HCCS	0.46
UQCRC2	0.458
PDSS1	0.456
YARS2	0.455
GATC	0.455
UBA5	0.453
KIAA0391	0.451
TAMM41	0.45
C17orf89	0.45
ELAC2	0.45
DAP3	0.449
WBSCR16	0.449
COX7B	0.447
SCO2	0.445
PLAA	0.444
MRPS14	0.444
NDUFAF4	0.443
SEC62	0.442
SLC25A3	0.442
PNPT1	0.441
GTF3C4	0.441
SDHA	0.44
TRMT10A	0.44
MRP63	0.44
GTF3C6	0.44
RTCB	0.439
CBFB	0.439
FAF2	0.437
CYCS	0.437
SELRC1	0.437
NDUFB3	0.437
MRPS26	0.436
MRPL20	0.436
TIMM22	0.434
BAP1	0.434
PPP6C	0.433
TMED10	0.433
TMEM41B	0.433
SLC35B1	0.432
SLC25A52	0.431
APAF1	0.431
TIMM13	0.431
DDX1	0.43
ZBTB11	0.428
ALG13	0.427
C10orf2	0.427
TSEN54	0.425
RTN4IP1	0.425
CTDNEP1	0.424
MRPS16	0.423
URM1	0.422
TUFM	0.422
UFM1	0.42
PELO	0.42
MRPL47	0.42
VMP1	0.419
ALG2	0.418
ELP3	0.418
MRPS21	0.417
GFM1	0.415
TRMT5	0.415
TEFM	0.412
NDUFB1	0.409
RFT1	0.409
DHRSX	0.409
RPUSD4	0.408
MRPS34	0.408
NAF1	0.406
UFSP2	0.406
PARS2	0.405
LAMTOR5	0.405
VARS2	0.405
CRLS1	0.404
CEPT1	0.403
PGM3	0.403
TTI1	0.403
GNB1L	0.401
CCDC101	0.401

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1640
Expression level (log2 read counts): 6.49

Expression Distribution

mitochondrial proton-transporting ATP synthase complex
proton-transporting ATP synthase activity, rotational mechanism
mitochondrial ATP synthesis coupled proton transport
energy coupled proton transport, down electrochemical gradient
ATP synthesis coupled proton transport
cristae formation
ATP biosynthetic process
inner mitochondrial membrane organization
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
drug binding
purine ribonucleoside triphosphate metabolic process
transmembrane transporter activity
nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
mitochondrial transmembrane transport
nucleoside triphosphate metabolic process
oxidative phosphorylation
mitochondrial membrane organization
proton transmembrane transport
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
ATP metabolic process
mitochondrial transport
ATPase activity
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy