TEFM

Gene Information

Official Symbol: TEFM
Official Name: transcription elongation factor, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 79736
UniProt: Q96QE5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery. {ECO:0000269|PubMed:21278163}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	1.75
Monensin 0.3μM R08 exp507	1.81
Doxorubicin 0.02μM R08 exp478	1.84
Phenformin 20μM R03 exp143	1.86
iCRT14 30μM R08 exp492	1.9
Aphidicolin 0.4μM R08 exp440	2
TIC10 10μM R08 exp532	2.01
Hydroxyurea 100μM R07 exp329	2.02
CI-1040 9.5μM R08 exp472	2.03
CR131-b 0.005μM R08 exp474	2.04
Mitomycin-C 0.06μM R08 exp503	2.13
Amiloride 100μM R08 exp447	2.14
Genistein 15μM R07 exp360	2.2
ONC212 0.15μM R08 exp513	2.2
Artemisinin 50μM R08 exp450	2.26
Olaparib 4μM R08 exp512	2.27
Sulforaphane 9μM R08 exp525	2.38
Thimerosal 0.85μM R08 exp529	2.43
PU-H71 1μM R08 exp515	2.59
GSK-J4 1.5μM R08 exp441	2.66
Oligomycin-A 2μM R00 exp25	2.98

Gene	Correlation
YARS2	0.687
MRPS21	0.657
NARS2	0.642
MRPS14	0.638
DARS2	0.614
EARS2	0.612
C10orf2	0.611
KIAA0391	0.606
MRPL53	0.605
MRPL21	0.605
GATC	0.603
RPUSD4	0.598
HSD17B10	0.592
GFM1	0.592
MRPS16	0.592
FTSJ2	0.592
MRPS6	0.591
TARS2	0.591
MRPS5	0.591
MRPS26	0.587
MRPL12	0.585
MRPS18A	0.584
DAP3	0.584
NDUFB11	0.582
LARS2	0.582
MRPL23	0.581
QRSL1	0.579
MRPS34	0.578
VARS2	0.576
NDUFA3	0.575
MRPS33	0.569
MARS2	0.568
MRP63	0.565
RARS2	0.564
PNPT1	0.562
NDUFAF7	0.562
MRPL47	0.562
MTERFD2	0.556
SELRC1	0.554
RNASEH1	0.552
MRPL15	0.552
PET112	0.549
GTPBP10	0.549
FASTKD5	0.547
SUPV3L1	0.545
RBFA	0.544
PARS2	0.542
MTRF1L	0.541
MRPL20	0.54
MRPS9	0.535
BCS1L	0.535
PDSS1	0.535
SCO2	0.534
ATP5SL	0.533
NDUFS7	0.531
SARS2	0.528
CARS2	0.525
WBSCR16	0.523
C12orf65	0.523
COX16	0.522
POLG	0.522
MRPS24	0.521
MRPS12	0.517
MRPL55	0.516
TUFM	0.515
MRPS10	0.507
RPUSD3	0.507
GFM2	0.506
NDUFB3	0.506
UQCR10	0.501
COQ2	0.5
MRPS2	0.498
NDUFA2	0.498
NDUFC2	0.497
HARS2	0.496
NDUFS2	0.495
POLG2	0.495
NDUFA1	0.493
NDUFV1	0.491
ATP5A1	0.491
NDUFAF4	0.49
C17orf89	0.489
ATP5D	0.486
MRPL45	0.482
ELAC2	0.48
MRPS17	0.48
AARS2	0.48
MRPL3	0.48
FARS2	0.477
MRPS25	0.476
TMEM242	0.475
GRSF1	0.474
TRUB2	0.474
METTL17	0.473
COX15	0.471
NDUFA11	0.471
NDUFAF3	0.47
MRPL41	0.47
SLC25A26	0.468
MTG2	0.466
NDUFS5	0.465
TOMM22	0.464
COQ3	0.463
MRPS11	0.463
NDUFB5	0.461
WARS2	0.46
UQCRC2	0.46
MTG1	0.46
ATP5B	0.459
TRMT10C	0.459
COX6C	0.458
POLRMT	0.458
COA6	0.457
HMGXB3	0.456
COQ4	0.455
TFAM	0.454
NDUFB9	0.454
COX5A	0.454
COX11	0.453
MRPL39	0.451
TIMMDC1	0.45
TOMM20	0.45
MIPEP	0.45
TMEM261	0.449
VPS41	0.448
MRPS23	0.447
MRPS7	0.445
ACAD9	0.445
COX20	0.443
RTN4IP1	0.443
MTPAP	0.443
MTIF3	0.442
MRPL11	0.442
MRPL44	0.441
DHRSX	0.44
HCCS	0.44
ECSIT	0.44
ALAS1	0.44
MRPL34	0.437
MRPL43	0.436
MRPL17	0.435
MINOS1	0.435
COQ7	0.435
COA3	0.434
MRPL42	0.434
CHCHD4	0.434
TFB1M	0.433
MRPL33	0.433
OPA1	0.433
MRPL35	0.43
MRPS22	0.429
COX7B	0.429
TMEM126B	0.428
RNMTL1	0.426
NDUFB6	0.425
MRPL18	0.424
TRMT10A	0.422
DHX30	0.421
ATP5H	0.421
FAM195A	0.42
KDSR	0.418
COX17	0.417
MRPL52	0.416
TRIAP1	0.415
DDX28	0.412
ATP5O	0.412
GLRX5	0.406
NDUFA8	0.406
ATP5J	0.405
NDUFC1	0.404
RPIA	0.404
MRPL13	0.403
NDUFS1	0.402
TRMT61A	0.402
ALG6	0.402
DOHH	0.402
CLPP	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2340
Expression level (log2 read counts): 4.05

Expression Distribution

transcription elongation from mitochondrial promoter
DNA polymerase processivity factor activity
crossover junction endodeoxyribonuclease activity
mitochondrial DNA replication
mitochondrial transcription
mitochondrial RNA metabolic process
mitochondrial nucleoid
DNA-templated transcription, elongation
oxidative phosphorylation
DNA-dependent DNA replication
mitochondrial gene expression
ribonucleoprotein complex
ATP metabolic process
DNA replication
mitochondrial matrix
generation of precursor metabolites and energy
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
phosphorylation
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression