SUPV3L1

Gene Information

Official Symbol: SUPV3L1
Official Name: Suv3 like RNA helicase
Aliases and Previous Symbols: N/A
Entrez ID: 6832
UniProt: Q8IYB8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ZLN024 50μM R08 exp538	-2.25
BH1 1μM R04 exp169	-2.22
Deguelin 0.05μM R02 exp69	-2.17
Nocodazole 0.02μM R00 exp23	-1.79
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.72
Hinokiflavone 12μM R08 exp487	1.76
Milciclib 2μM R08 exp502	1.78
CR131-b 0.005μM R08 exp474	1.8
Bleomycin 5μM R08 exp459	1.81
ONC212 0.15μM R08 exp513	1.87
Deferoxamine 11μM R07 exp350	1.88
PU-H71 1μM R08 exp515	1.88
AICAR 240μM R03 exp116	1.89
TIC10 10μM R08 exp532	1.95
Tanespimycin 14μM R08 exp527	2.02
BI-D1870 3.15μM R02 exp66	2.08
CI-1040 9.5μM R08 exp472	2.13
Ammonium tetrathiomolybdate 10μM R08 exp448	2.14
Thimerosal 0.85μM R08 exp529	2.14
Atovaquone 15μM R08 exp451	2.63
Hydroxyurea 100μM R07 exp329	2.63
AICAR 240μM R05 exp211	2.69
CFI-400945 25μM R08 exp469	2.84
42°C R08 exp539	2.98
GSK-J4 1.5μM R08 exp441	3.7

Gene	Correlation
MRPL21	0.708
HSD17B10	0.7
MRP63	0.699
MRPS14	0.667
SLC25A26	0.664
COX16	0.657
YARS2	0.654
MRPS18A	0.649
MRPS34	0.649
MRPS6	0.647
MRPL23	0.645
MRPS16	0.635
KIAA0391	0.631
SARS2	0.628
TUFM	0.628
DAP3	0.627
MRPS21	0.626
DARS2	0.621
SCO2	0.614
WBSCR16	0.612
MRPL53	0.611
TARS2	0.608
SELRC1	0.607
GFM1	0.607
BCS1L	0.607
MRPS5	0.605
VARS2	0.599
TRIAP1	0.597
RPUSD4	0.596
MRPS9	0.596
PNPT1	0.59
NDUFA3	0.589
UQCRC2	0.588
ATP5A1	0.586
MRPL47	0.577
ELAC2	0.577
MRPS26	0.567
QRSL1	0.565
PDSS1	0.563
RBFA	0.563
TRUB2	0.563
COX7B	0.562
MRPL34	0.555
HCCS	0.554
NARS2	0.554
MRPL36	0.553
MRPL15	0.553
RNASEH1	0.552
FARS2	0.552
PMM2	0.551
PARS2	0.551
DOHH	0.55
MRPS23	0.55
C12orf65	0.549
TMEM242	0.549
MTPAP	0.548
CHCHD4	0.548
EARS2	0.547
MRPL20	0.547
MRPS10	0.546
TEFM	0.545
MRPS2	0.543
ALG1	0.543
AASDHPPT	0.54
THG1L	0.539
RARS2	0.538
ATP5D	0.538
DPAGT1	0.538
MRPS11	0.538
FASTKD5	0.537
MRPS12	0.537
MRPL42	0.537
GFM2	0.535
MRPL44	0.534
NDUFAF4	0.533
MRPS25	0.533
MRPL55	0.532
MRPS33	0.531
HARS2	0.529
MRPS24	0.528
C10orf2	0.526
MRPL33	0.526
NDUFB11	0.525
CRLS1	0.524
ATP5B	0.523
C17orf89	0.522
GTPBP10	0.521
ROMO1	0.52
PPCS	0.519
TAZ	0.519
ATXN10	0.517
COX6C	0.517
AIFM1	0.516
COQ3	0.515
MARS2	0.513
MRPL45	0.513
TAMM41	0.511
NDUFAF7	0.51
UAP1	0.51
MRPL12	0.51
NDUFB5	0.506
GATC	0.506
UQCR10	0.505
MTG2	0.504
ATP5O	0.502
RPE	0.501
UHRF1	0.497
TFAM	0.495
RPIA	0.494
MRPL3	0.493
TRNT1	0.492
HIGD2A	0.491
NDUFC2	0.49
COA5	0.489
LARS2	0.489
ATP5C1	0.488
COX17	0.487
DHRSX	0.486
FH	0.486
COQ2	0.484
TTC4	0.484
UQCRQ	0.481
MRPL18	0.48
MRPL41	0.478
TIMM8B	0.476
ATP5J	0.475
COX15	0.474
TPK1	0.473
OPA1	0.472
DHX30	0.472
NDUFA1	0.47
MRPS17	0.469
ATP5H	0.468
VEZT	0.467
MBTPS2	0.467
GTF3C6	0.467
MRPL11	0.466
MRPL27	0.466
ALG13	0.466
SSB	0.465
TOMM40	0.464
FTSJ2	0.462
TOMM22	0.461
NDUFB6	0.461
MRPL22	0.46
CYCS	0.456
PPA2	0.456
COA3	0.455
MTRF1L	0.455
TMEM41B	0.454
GFER	0.453
DNLZ	0.452
MRPL52	0.451
TMEM126B	0.451
TOMM20	0.45
GMPPB	0.45
SRP14	0.45
NDUFAF3	0.45
GFPT1	0.449
RPTOR	0.447
NDUFB3	0.447
BAP1	0.446
ADSL	0.446
MTG1	0.445
LSM10	0.442
COA6	0.442
MRPL13	0.441
SLC25A19	0.441
TRMT10A	0.439
LRPPRC	0.439
TRMT5	0.438
NDUFB1	0.438
RTCB	0.437
FASTKD1	0.437
ZRSR2	0.436
MRPS22	0.436
CBFB	0.435
MRPL46	0.433
ALG6	0.432
NDUFA2	0.432
TIMM13	0.431
NDUFS7	0.43
POLG	0.43
NFU1	0.43
NDUFV1	0.43
DHPS	0.429
EIF3F	0.428
TXNL4B	0.428
COQ5	0.427
PGM3	0.427
TRMT10C	0.427
COX6B1	0.427
MRPL4	0.426
AARS2	0.426
ALG5	0.426
MRPL32	0.426
ATIC	0.425
GLRX5	0.423
LAMTOR4	0.423
COX10	0.421
COX5A	0.42
TIMM17A	0.419
HAUS8	0.417
CBX3	0.417
PTRHD1	0.417
UQCC2	0.417
UQCRC1	0.417
RTN4IP1	0.417
CASP9	0.416
COQ4	0.416
PGGT1B	0.415
MRPS7	0.414
MIPEP	0.413
RPUSD3	0.412
MTERFD2	0.412
RNMTL1	0.412
IBA57	0.411
MRPL39	0.41
KDSR	0.41
SEC62	0.41
POLRMT	0.408
POLG2	0.407
UBE2G2	0.406
MRPL28	0.406
PET112	0.405
TRMT61A	0.404
ENY2	0.403
MTFMT	0.402
MRPL17	0.402
NDUFB9	0.401
RNMT	0.401
ISCA2	0.401
GEMIN8	0.4

Global Fraction of Cell Lines Where Essential: 533/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	24/28
blood	21/28
bone	14/26
breast	25/33
central nervous system	40/56
cervix	4/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	12/16
kidney	12/21
liver	15/20
lung	54/75
lymphocyte	13/16
ovary	15/26
pancreas	17/24
peripheral nervous system	6/16
plasma cell	10/15
prostate	0/1
skin	19/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	21/22
urinary tract	25/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 124
Expression level (log2 read counts): 6.02

Expression Distribution

Helicase C
SUV3 C

mitochondrial ncRNA surveillance
cytoplasmic RNA surveillance
mitochondrial RNA surveillance
mitochondrial mRNA surveillance
positive regulation of mitochondrial RNA catabolic process
mitochondrial degradosome
mitochondrial RNA catabolic process
mitochondrial mRNA catabolic process
chromatin maintenance
regulation of mitochondrial RNA catabolic process
mitochondrial RNA 3-end processing
RNA surveillance
mitochondrial RNA processing
3-5 RNA helicase activity
mitochondrion morphogenesis
helicase activity
mitochondrial RNA metabolic process
mitochondrial nucleoid
cellular component maintenance
DNA helicase activity
RNA helicase activity
double-stranded RNA binding
DNA duplex unwinding
DNA geometric change
RNA 3-end processing
mitochondrial gene expression
positive regulation of cell growth
mRNA catabolic process
DNA recombination
RNA catabolic process
positive regulation of growth
DNA conformation change
positive regulation of cellular catabolic process
mitochondrial matrix
nucleobase-containing compound catabolic process
regulation of cell growth
positive regulation of catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
mitochondrion organization