COX10

Official Symbol: COX10
Official Name: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Aliases and Previous Symbols: N/A
Entrez ID: 1352
UniProt: Q12887
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008].
UniProt Summary: Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	3/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heme o metabolic process
protoheme IX farnesyltransferase activity
heme O biosynthetic process
heme a biosynthetic process
farnesyltranstransferase activity
heme a metabolic process
cytochrome complex
mitochondrial fission
mitochondrial electron transport, cytochrome c to oxygen
aerobic electron transport chain
heme biosynthetic process
respiratory chain complex IV assembly
porphyrin-containing compound biosynthetic process
cytochrome-c oxidase activity
tetrapyrrole biosynthetic process
heme metabolic process
cytochrome complex assembly
porphyrin-containing compound metabolic process
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
cofactor biosynthetic process
energy derivation by oxidation of organic compounds
organelle fission
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
cofactor metabolic process
mitochondrion organization
inorganic cation transmembrane transport
cation transmembrane transport