COX10 [The Human Chemical-Genetic Interaction Map Project]

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======= COX10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX10
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1352|1352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12887|Q12887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UbiA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heme o metabolic process|
|protoheme IX farnesyltransferase activity|
|heme O biosynthetic process|
|heme a biosynthetic process|
|farnesyltranstransferase activity|
|heme a metabolic process|
|cytochrome complex|
|mitochondrial fission|
|mitochondrial electron transport, cytochrome c to oxygen|
|aerobic electron transport chain|
|heme biosynthetic process|
|respiratory chain complex IV assembly|
|porphyrin-containing compound biosynthetic process|
|cytochrome-c oxidase activity|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|cytochrome complex assembly|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|proton transmembrane transport|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|cofactor biosynthetic process|
|energy derivation by oxidation of organic compounds|
|organelle fission|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|nucleolus|
|ion transmembrane transport|
|oxidation-reduction process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.96|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.9|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.84|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.79|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.77|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.76|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.71|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.7|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.71|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.79|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.83|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:s:sco2|SCO2]]|0.433|
|[[:human genes:v:vars2|VARS2]]|0.423|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.421|
|[[:human genes:c:cox6b1|COX6B1]]|0.42|
|[[:human genes:s:selrc1|SELRC1]]|0.415|
|[[:human genes:c:cox7b|COX7B]]|0.412|
|[[:human genes:m:mrps18a|MRPS18A]]|0.408|
|[[:human genes:p:pdss1|PDSS1]]|0.402|
|[[:human genes:m:mrpl21|MRPL21]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX10 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>