TXNL4B

Entrez Summary: N/A
UniProt Summary: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lenalidomide 20μM R07 exp375	-2.39
TRAIL 50ng/ml R00 exp36	-2.19
Thalidomide 20μM R07 exp406	-2.12
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.11
PFI-2 4μM R05 exp239	-2.1
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.1
Asunaprenir 3μM R07 exp336	-2.06
DABN 2μM R00 exp16	-2.02
Lapatinib 5μM R01 exp47	-1.99
Adefovir 20μM R07 exp332	-1.97
Parthenolide 2.5μM R05 exp238	-1.91
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	-1.84
Nicotinamide 2000μM R01 exp50	-1.81
2-Methoxyestradiol 0.55μM R07 exp310	-1.78
GSK591 2.6μM R03 exp128	-1.78
S-trityl-L-cysteine 0.5μM R05 exp243	-1.77
BRD2 inhibitor II 20μM R07 exp341	-1.73
Losmapimod 1μM R07 exp376	-1.73
Cincreasin 100μM R08 exp473	-1.71
Aminopterin 0.005μM R07 exp335	-1.7
Rotenone 20μM R00 exp34	1.73
HMS-I2 10μM R06 exp288	1.8
SNS-032 25μM R07 exp401	2.31

Global Fraction of Cell Lines Where Essential: 84/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	4/28
bone	6/26
breast	8/33
central nervous system	5/56
cervix	1/4
colorectal	1/17
esophagus	2/13
fibroblast	1/1
gastric	3/16
kidney	1/21
liver	1/20
lung	5/75
lymphocyte	3/16
ovary	2/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

U5 snRNP
U4/U6 x U5 tri-snRNP complex
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
cell cycle
RNA metabolic process
gene expression