TTC4

Entrez Summary: This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TGF-beta1 44ng/ml R08 exp528	-2.29
Fas-L 44ng/ml R08 exp482	-2.16
Rapamycin 1μM R00 exp29	-1.96
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.83
Ribavirin 10μM R01 exp52	-1.79
Rifampicin 1μM R00 exp31	-1.78
Deferoxamine 11μM R07 exp350	1.84
GSK-J4 1-1.25μM to day4 R07 exp363	2
CB-839 10μM R05 exp224	2.04
GSK461364A 0.1μM R03 exp126	2.31
DABN racemic mixture R03 exp93	2.33

Global Fraction of Cell Lines Where Essential: 197/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	3/28
bone	9/26
breast	5/33
central nervous system	21/56
cervix	0/4
colorectal	6/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	10/21
liver	4/20
lung	22/75
lymphocyte	5/16
ovary	6/26
pancreas	4/24
peripheral nervous system	5/16
plasma cell	3/15
prostate	0/1
skin	4/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	9/22
urinary tract	8/29
uterus	1/5

Expression Distribution