MED4
Gene Information
- Official Symbol: MED4
- Official Name: mediator complex subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 29079
- UniProt: Q9NPJ6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Med4 |
GO Terms
| core mediator complex |
| vitamin D receptor binding |
| thyroid hormone receptor binding |
| mediator complex |
| nuclear receptor transcription coactivator activity |
| transcription coregulator activity |
| transcription initiation from RNA polymerase II promoter |
| DNA-templated transcription, initiation |
| transcription by RNA polymerase II |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ADSL | 0.567 |
| THG1L | 0.563 |
| DPAGT1 | 0.561 |
| MED16 | 0.554 |
| ATXN10 | 0.554 |
| GMPPB | 0.547 |
| RTCB | 0.526 |
| ALG1 | 0.514 |
| RPTOR | 0.509 |
| UXT | 0.504 |
| RNMT | 0.494 |
| CCDC101 | 0.483 |
| GFPT1 | 0.481 |
| PMM2 | 0.479 |
| GPN2 | 0.465 |
| AARS | 0.459 |
| UAP1 | 0.459 |
| MLLT1 | 0.456 |
| UHRF1 | 0.455 |
| PELO | 0.454 |
| EPRS | 0.454 |
| EIF4E | 0.452 |
| TRMT5 | 0.45 |
| LAMTOR5 | 0.449 |
| YARS | 0.444 |
| SRP68 | 0.443 |
| RPP21 | 0.443 |
| TTI2 | 0.442 |
| ORAOV1 | 0.442 |
| TRIAP1 | 0.439 |
| ERCC2 | 0.439 |
| SRP14 | 0.437 |
| ALG13 | 0.437 |
| ALG2 | 0.434 |
| TRMT10A | 0.432 |
| TCF4 | 0.432 |
| FNTA | 0.426 |
| DR1 | 0.425 |
| GTF3C2 | 0.425 |
| MAPK14 | 0.423 |
| ELAC2 | 0.423 |
| ATP5J | 0.422 |
| DOLK | 0.422 |
| EEF1E1 | 0.422 |
| TPRKB | 0.421 |
| VHL | 0.421 |
| TTI1 | 0.42 |
| NAE1 | 0.42 |
| ENY2 | 0.418 |
| LSMD1 | 0.417 |
| TTC4 | 0.414 |
| EXOC4 | 0.414 |
| VEZT | 0.412 |
| GEMIN6 | 0.411 |
| TMEM41B | 0.407 |
| OSGEP | 0.406 |
| TRNT1 | 0.406 |
| CSNK2B | 0.404 |
| SLC25A19 | 0.404 |
| GNB1L | 0.404 |
| NARS | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 521/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 25/28 |
| blood | 21/28 |
| bone | 17/25 |
| breast | 26/33 |
| central nervous system | 42/56 |
| cervix | 4/4 |
| colorectal | 13/17 |
| esophagus | 9/13 |
| fibroblast | 1/1 |
| gastric | 11/15 |
| kidney | 13/21 |
| liver | 14/20 |
| lung | 58/75 |
| lymphocyte | 8/14 |
| ovary | 22/26 |
| pancreas | 18/24 |
| peripheral nervous system | 9/16 |
| plasma cell | 12/15 |
| prostate | 1/1 |
| skin | 15/24 |
| soft tissue | 7/7 |
| thyroid | 2/2 |
| upper aerodigestive | 15/22 |
| urinary tract | 22/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 4218
- Expression level (log2 read counts): 5.59
Expression Distribution
MED4 Expression in NALM6 Cells: 5.59
