MED4 [The Human Chemical-Genetic Interaction Map Project]

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======= MED4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED4
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29079|29079]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPJ6|Q9NPJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605718|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core mediator complex|
|vitamin D receptor binding|
|thyroid hormone receptor binding|
|mediator complex|
|nuclear receptor transcription coactivator activity|
|transcription coregulator activity|
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.28|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.12|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.96|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.92|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.87|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.82|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.79|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.76|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.71|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.75|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.78|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.88|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:adsl|ADSL]]|0.567|
|[[:human genes:t:thg1l|THG1L]]|0.563|
|[[:human genes:d:dpagt1|DPAGT1]]|0.561|
|[[:human genes:m:med16|MED16]]|0.554|
|[[:human genes:a:atxn10|ATXN10]]|0.554|
|[[:human genes:g:gmppb|GMPPB]]|0.547|
|[[:human genes:r:rtcb|RTCB]]|0.526|
|[[:human genes:a:alg1|ALG1]]|0.514|
|[[:human genes:r:rptor|RPTOR]]|0.509|
|[[:human genes:u:uxt|UXT]]|0.504|
|[[:human genes:r:rnmt|RNMT]]|0.494|
|[[:human genes:c:ccdc101|CCDC101]]|0.483|
|[[:human genes:g:gfpt1|GFPT1]]|0.481|
|[[:human genes:p:pmm2|PMM2]]|0.479|
|[[:human genes:g:gpn2|GPN2]]|0.465|
|[[:human genes:a:aars|AARS]]|0.459|
|[[:human genes:u:uap1|UAP1]]|0.459|
|[[:human genes:m:mllt1|MLLT1]]|0.456|
|[[:human genes:u:uhrf1|UHRF1]]|0.455|
|[[:human genes:p:pelo|PELO]]|0.454|
|[[:human genes:e:eprs|EPRS]]|0.454|
|[[:human genes:e:eif4e|EIF4E]]|0.452|
|[[:human genes:t:trmt5|TRMT5]]|0.45|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.449|
|[[:human genes:y:yars|YARS]]|0.444|
|[[:human genes:s:srp68|SRP68]]|0.443|
|[[:human genes:r:rpp21|RPP21]]|0.443|
|[[:human genes:t:tti2|TTI2]]|0.442|
|[[:human genes:o:oraov1|ORAOV1]]|0.442|
|[[:human genes:t:triap1|TRIAP1]]|0.439|
|[[:human genes:e:ercc2|ERCC2]]|0.439|
|[[:human genes:s:srp14|SRP14]]|0.437|
|[[:human genes:a:alg13|ALG13]]|0.437|
|[[:human genes:a:alg2|ALG2]]|0.434|
|[[:human genes:t:trmt10a|TRMT10A]]|0.432|
|[[:human genes:t:tcf4|TCF4]]|0.432|
|[[:human genes:f:fnta|FNTA]]|0.426|
|[[:human genes:d:dr1|DR1]]|0.425|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.425|
|[[:human genes:m:mapk14|MAPK14]]|0.423|
|[[:human genes:e:elac2|ELAC2]]|0.423|
|[[:human genes:a:atp5j|ATP5J]]|0.422|
|[[:human genes:d:dolk|DOLK]]|0.422|
|[[:human genes:e:eef1e1|EEF1E1]]|0.422|
|[[:human genes:t:tprkb|TPRKB]]|0.421|
|[[:human genes:v:vhl|VHL]]|0.421|
|[[:human genes:t:tti1|TTI1]]|0.42|
|[[:human genes:n:nae1|NAE1]]|0.42|
|[[:human genes:e:eny2|ENY2]]|0.418|
|[[:human genes:l:lsmd1|LSMD1]]|0.417|
|[[:human genes:t:ttc4|TTC4]]|0.414|
|[[:human genes:e:exoc4|EXOC4]]|0.414|
|[[:human genes:v:vezt|VEZT]]|0.412|
|[[:human genes:g:gemin6|GEMIN6]]|0.411|
|[[:human genes:t:tmem41b|TMEM41B]]|0.407|
|[[:human genes:o:osgep|OSGEP]]|0.406|
|[[:human genes:t:trnt1|TRNT1]]|0.406|
|[[:human genes:c:csnk2b|CSNK2B]]|0.404|
|[[:human genes:s:slc25a19|SLC25A19]]|0.404|
|[[:human genes:g:gnb1l|GNB1L]]|0.404|
|[[:human genes:n:nars|NARS]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 521/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|25/28|
|blood|21/28|
|bone|17/25|
|breast|26/33|
|central nervous system|42/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|13/21|
|liver|14/20|
|lung|58/75|
|lymphocyte|8/14|
|ovary|22/26|
|pancreas|18/24|
|peripheral nervous system|9/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED4 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>