NARS
Gene Information
- Official Symbol: N/ARS1
- Official Name: asparaginyl-tRNA synthetase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4677
- UniProt: O43776
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| tRNA-synt 2 |
| tRNA anti |
GO Terms
| asparagine-tRNA ligase activity |
| asparaginyl-tRNA aminoacylation |
| tRNA aminoacylation for protein translation |
| tRNA aminoacylation |
| amino acid activation |
| tRNA metabolic process |
| nucleic acid binding |
| cellular amino acid metabolic process |
| translation |
| peptide biosynthetic process |
| ncRNA metabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| carboxylic acid metabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.718 |
| GMPPB | 0.632 |
| RNMT | 0.601 |
| CCT7 | 0.59 |
| EIF4E | 0.566 |
| MARS | 0.557 |
| YARS | 0.551 |
| HSPD1 | 0.544 |
| AARS | 0.544 |
| CSNK2B | 0.534 |
| RTCB | 0.532 |
| RPTOR | 0.532 |
| NSMCE1 | 0.527 |
| ALG1 | 0.526 |
| GFPT1 | 0.515 |
| SPCS3 | 0.51 |
| EPRS | 0.51 |
| OSGEP | 0.501 |
| TTI2 | 0.501 |
| GTF3C2 | 0.5 |
| DPAGT1 | 0.497 |
| ZNF259 | 0.497 |
| SRP68 | 0.489 |
| SLC35B1 | 0.489 |
| TELO2 | 0.488 |
| PMM2 | 0.486 |
| MEAF6 | 0.48 |
| MTOR | 0.48 |
| GTF3C3 | 0.479 |
| PAM16 | 0.479 |
| UAP1 | 0.479 |
| TRMT5 | 0.478 |
| PELO | 0.478 |
| TBCD | 0.477 |
| CARS | 0.477 |
| UXT | 0.476 |
| CCDC101 | 0.476 |
| VRK1 | 0.475 |
| TTI1 | 0.474 |
| SEH1L | 0.473 |
| SPCS2 | 0.473 |
| OTUD5 | 0.469 |
| POLR3B | 0.466 |
| DHPS | 0.465 |
| THOC3 | 0.464 |
| PPP2R3C | 0.464 |
| RPN1 | 0.463 |
| ALG2 | 0.463 |
| THG1L | 0.452 |
| ENY2 | 0.452 |
| MAPK14 | 0.451 |
| ALG14 | 0.451 |
| GNB1L | 0.449 |
| GEMIN5 | 0.449 |
| ATP5J | 0.449 |
| DPF2 | 0.446 |
| TRIAP1 | 0.446 |
| ATXN10 | 0.446 |
| HAUS8 | 0.446 |
| TSEN34 | 0.445 |
| TBCA | 0.445 |
| LSM11 | 0.445 |
| DAD1 | 0.442 |
| ABCB7 | 0.44 |
| MED16 | 0.439 |
| ALG13 | 0.439 |
| ADSL | 0.437 |
| RAD1 | 0.434 |
| WARS | 0.432 |
| DHX29 | 0.431 |
| UHRF1 | 0.429 |
| IARS2 | 0.428 |
| DDX20 | 0.428 |
| OIP5 | 0.426 |
| ALG5 | 0.425 |
| KARS | 0.424 |
| NAE1 | 0.424 |
| EXOC4 | 0.421 |
| BAP1 | 0.421 |
| ZRSR2 | 0.42 |
| DHDDS | 0.419 |
| NSMCE2 | 0.419 |
| SRP72 | 0.416 |
| GTF3C6 | 0.414 |
| ORAOV1 | 0.413 |
| POLR3H | 0.413 |
| DICER1 | 0.411 |
| TGS1 | 0.41 |
| UTP23 | 0.409 |
| RPP21 | 0.409 |
| EIF5A | 0.407 |
| TMEM41B | 0.407 |
| CEP350 | 0.406 |
| MED4 | 0.402 |
| TRNT1 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 734/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 26/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 19/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 43
- Expression level (log2 read counts): 7.95
Expression Distribution
NARS Expression in NALM6 Cells: 7.95
