NARS [The Human Chemical-Genetic Interaction Map Project]

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======= NARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ARS1
  * **<color #00a2e8>Official Name</color>**: asparaginyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4677|4677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43776|O43776]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2|
|tRNA anti|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|asparagine-tRNA ligase activity|
|asparaginyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|nucleic acid binding|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.67|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.09|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.89|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.85|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.8|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.78|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.77|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.74|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.74|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.72|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.72|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.91|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.92|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.96|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.04|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.37|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.718|
|[[:human genes:g:gmppb|GMPPB]]|0.632|
|[[:human genes:r:rnmt|RNMT]]|0.601|
|[[:human genes:c:cct7|CCT7]]|0.59|
|[[:human genes:e:eif4e|EIF4E]]|0.566|
|[[:human genes:m:mars|MARS]]|0.557|
|[[:human genes:y:yars|YARS]]|0.551|
|[[:human genes:h:hspd1|HSPD1]]|0.544|
|[[:human genes:a:aars|AARS]]|0.544|
|[[:human genes:c:csnk2b|CSNK2B]]|0.534|
|[[:human genes:r:rtcb|RTCB]]|0.532|
|[[:human genes:r:rptor|RPTOR]]|0.532|
|[[:human genes:n:nsmce1|NSMCE1]]|0.527|
|[[:human genes:a:alg1|ALG1]]|0.526|
|[[:human genes:g:gfpt1|GFPT1]]|0.515|
|[[:human genes:s:spcs3|SPCS3]]|0.51|
|[[:human genes:e:eprs|EPRS]]|0.51|
|[[:human genes:o:osgep|OSGEP]]|0.501|
|[[:human genes:t:tti2|TTI2]]|0.501|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.5|
|[[:human genes:d:dpagt1|DPAGT1]]|0.497|
|[[:human genes:z:znf259|ZNF259]]|0.497|
|[[:human genes:s:srp68|SRP68]]|0.489|
|[[:human genes:s:slc35b1|SLC35B1]]|0.489|
|[[:human genes:t:telo2|TELO2]]|0.488|
|[[:human genes:p:pmm2|PMM2]]|0.486|
|[[:human genes:m:meaf6|MEAF6]]|0.48|
|[[:human genes:m:mtor|MTOR]]|0.48|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.479|
|[[:human genes:p:pam16|PAM16]]|0.479|
|[[:human genes:u:uap1|UAP1]]|0.479|
|[[:human genes:t:trmt5|TRMT5]]|0.478|
|[[:human genes:p:pelo|PELO]]|0.478|
|[[:human genes:t:tbcd|TBCD]]|0.477|
|[[:human genes:c:cars|CARS]]|0.477|
|[[:human genes:u:uxt|UXT]]|0.476|
|[[:human genes:c:ccdc101|CCDC101]]|0.476|
|[[:human genes:v:vrk1|VRK1]]|0.475|
|[[:human genes:t:tti1|TTI1]]|0.474|
|[[:human genes:s:seh1l|SEH1L]]|0.473|
|[[:human genes:s:spcs2|SPCS2]]|0.473|
|[[:human genes:o:otud5|OTUD5]]|0.469|
|[[:human genes:p:polr3b|POLR3B]]|0.466|
|[[:human genes:d:dhps|DHPS]]|0.465|
|[[:human genes:t:thoc3|THOC3]]|0.464|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.464|
|[[:human genes:r:rpn1|RPN1]]|0.463|
|[[:human genes:a:alg2|ALG2]]|0.463|
|[[:human genes:t:thg1l|THG1L]]|0.452|
|[[:human genes:e:eny2|ENY2]]|0.452|
|[[:human genes:m:mapk14|MAPK14]]|0.451|
|[[:human genes:a:alg14|ALG14]]|0.451|
|[[:human genes:g:gnb1l|GNB1L]]|0.449|
|[[:human genes:g:gemin5|GEMIN5]]|0.449|
|[[:human genes:a:atp5j|ATP5J]]|0.449|
|[[:human genes:d:dpf2|DPF2]]|0.446|
|[[:human genes:t:triap1|TRIAP1]]|0.446|
|[[:human genes:a:atxn10|ATXN10]]|0.446|
|[[:human genes:h:haus8|HAUS8]]|0.446|
|[[:human genes:t:tsen34|TSEN34]]|0.445|
|[[:human genes:t:tbca|TBCA]]|0.445|
|[[:human genes:l:lsm11|LSM11]]|0.445|
|[[:human genes:d:dad1|DAD1]]|0.442|
|[[:human genes:a:abcb7|ABCB7]]|0.44|
|[[:human genes:m:med16|MED16]]|0.439|
|[[:human genes:a:alg13|ALG13]]|0.439|
|[[:human genes:a:adsl|ADSL]]|0.437|
|[[:human genes:r:rad1|RAD1]]|0.434|
|[[:human genes:w:wars|WARS]]|0.432|
|[[:human genes:d:dhx29|DHX29]]|0.431|
|[[:human genes:u:uhrf1|UHRF1]]|0.429|
|[[:human genes:i:iars2|IARS2]]|0.428|
|[[:human genes:d:ddx20|DDX20]]|0.428|
|[[:human genes:o:oip5|OIP5]]|0.426|
|[[:human genes:a:alg5|ALG5]]|0.425|
|[[:human genes:k:kars|KARS]]|0.424|
|[[:human genes:n:nae1|NAE1]]|0.424|
|[[:human genes:e:exoc4|EXOC4]]|0.421|
|[[:human genes:b:bap1|BAP1]]|0.421|
|[[:human genes:z:zrsr2|ZRSR2]]|0.42|
|[[:human genes:d:dhdds|DHDDS]]|0.419|
|[[:human genes:n:nsmce2|NSMCE2]]|0.419|
|[[:human genes:s:srp72|SRP72]]|0.416|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.414|
|[[:human genes:o:oraov1|ORAOV1]]|0.413|
|[[:human genes:p:polr3h|POLR3H]]|0.413|
|[[:human genes:d:dicer1|DICER1]]|0.411|
|[[:human genes:t:tgs1|TGS1]]|0.41|
|[[:human genes:u:utp23|UTP23]]|0.409|
|[[:human genes:r:rpp21|RPP21]]|0.409|
|[[:human genes:e:eif5a|EIF5A]]|0.407|
|[[:human genes:t:tmem41b|TMEM41B]]|0.407|
|[[:human genes:c:cep350|CEP350]]|0.406|
|[[:human genes:m:med4|MED4]]|0.402|
|[[:human genes:t:trnt1|TRNT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 43
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NARS Expression in NALM6 Cells: 7.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>