ZNF259
Gene Information
- Official Symbol: ZPR1
- Official Name: ZPR1 zinc finger
- Aliases and Previous Symbols: N/A
- Entrez ID: 8882
- UniProt: O75312
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766}.
Pfam Domains GO Terms
Pfam Domains
| zf-ZPR1 |
GO Terms
| pre-mRNA catabolic process |
| DNA endoreduplication |
| trophectodermal cell proliferation |
| positive regulation of transcription involved in G1/S transition of mitotic cell cycle |
| negative regulation of motor neuron apoptotic process |
| Cajal body organization |
| regulation of motor neuron apoptotic process |
| Gemini of coiled bodies |
| inner cell mass cell proliferation |
| nuclear body organization |
| blastocyst growth |
| translation initiation factor binding |
| apoptotic process involved in development |
| regulation of transcription involved in G1/S transition of mitotic cell cycle |
| positive regulation of RNA splicing |
| positive regulation of protein import into nucleus |
| positive regulation of protein import |
| regulation of myelination |
| cellular response to epidermal growth factor stimulus |
| cell cycle DNA replication |
| response to epidermal growth factor |
| Cajal body |
| regulation of protein import into nucleus |
| receptor tyrosine kinase binding |
| regulation of protein import |
| positive regulation of nucleocytoplasmic transport |
| positive regulation of protein localization to nucleus |
| blastocyst development |
| regulation of nucleocytoplasmic transport |
| spinal cord development |
| regulation of protein localization to nucleus |
| G1/S transition of mitotic cell cycle |
| DNA-dependent DNA replication |
| cell cycle G1/S phase transition |
| growth cone |
| nucleus organization |
| perikaryon |
| regulation of RNA splicing |
| negative regulation of neuron apoptotic process |
| positive regulation of intracellular protein transport |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| positive regulation of intracellular transport |
| DNA replication |
| regulation of intracellular protein transport |
| RNA catabolic process |
| positive regulation of growth |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| axon |
| regulation of neuron death |
| positive regulation of cellular protein localization |
| regulation of intracellular transport |
| neuronal cell body |
| nucleobase-containing compound catabolic process |
| in utero embryonic development |
| developmental growth |
| growth |
| RNA splicing |
| axon development |
| positive regulation of protein transport |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| positive regulation of establishment of protein localization |
| microtubule cytoskeleton organization |
| mRNA processing |
| organic cyclic compound catabolic process |
| cellular response to growth factor stimulus |
| response to growth factor |
| regulation of cellular protein localization |
| cell population proliferation |
| mitotic cell cycle process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| neuron projection development |
| regulation of growth |
| microtubule-based process |
| mitotic cell cycle |
| mRNA metabolic process |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| neuron development |
| zinc ion binding |
| nucleolus |
| RNA processing |
| negative regulation of apoptotic process |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| apoptotic process |
| regulation of nervous system development |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| negative regulation of cell death |
| cell cycle process |
| neuron differentiation |
| regulation of protein localization |
| macromolecule catabolic process |
| programmed cell death |
| cell death |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cellular response to endogenous stimulus |
| cell cycle |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.638 |
| GNB1L | 0.525 |
| RNMT | 0.514 |
| SRP68 | 0.511 |
| NARS | 0.497 |
| TTI2 | 0.496 |
| GMPPB | 0.483 |
| GFPT1 | 0.472 |
| PMM2 | 0.468 |
| DAD1 | 0.467 |
| GTF3C2 | 0.466 |
| EIF4E | 0.458 |
| SPCS3 | 0.456 |
| VRK1 | 0.45 |
| TSEN54 | 0.449 |
| POLR3B | 0.444 |
| MED16 | 0.444 |
| CCDC101 | 0.442 |
| TELO2 | 0.441 |
| YARS | 0.44 |
| RPTOR | 0.439 |
| GTF3C3 | 0.439 |
| POLR3H | 0.436 |
| MEAF6 | 0.436 |
| FARSB | 0.436 |
| TSEN2 | 0.436 |
| AARS | 0.435 |
| RAD1 | 0.435 |
| DPAGT1 | 0.434 |
| ERCC2 | 0.433 |
| OSGEP | 0.432 |
| PELO | 0.431 |
| HAUS8 | 0.428 |
| RPN1 | 0.428 |
| MARS | 0.426 |
| TTI1 | 0.426 |
| DDOST | 0.425 |
| DHDDS | 0.423 |
| NSMCE1 | 0.423 |
| ALG1 | 0.422 |
| RTCB | 0.422 |
| EPRS | 0.42 |
| ALG13 | 0.419 |
| THOC3 | 0.417 |
| DPF2 | 0.416 |
| TBCA | 0.416 |
| DHPS | 0.415 |
| SEH1L | 0.412 |
| CCT7 | 0.41 |
| SRPRB | 0.41 |
| ORAOV1 | 0.408 |
| WARS | 0.406 |
| GEMIN5 | 0.405 |
| THG1L | 0.403 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 732/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1346
- Expression level (log2 read counts): 6.49
Expression Distribution
ZNF259 Expression in NALM6 Cells: 6.49
