SRP68

Entrez Summary: N/A
UniProt Summary: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcipotriol 5μM R08 exp464	-2.07
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.97
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.94
5-Fluorouracil 2μM R00 exp1	-1.9
MS094 2μM R03 exp136	-1.9
Thalidomide 20μM R07 exp406	-1.9
Rapamycin 0.001μM R08 exp429	-1.87
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.82
Lenalidomide 20μM R07 exp375	-1.78
THZ531 0.11μM R07 exp409	-1.76
NFN1 0.1μM R01 exp49	-1.75
Pyronaridine 1μM R06 exp295	-1.71
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.7
BI-2536 0.02μM R03 exp96	1.84
Etoposide 1μM R00 exp19	1.87
Actinomycin-D 0.01μM R00 exp4	3.33

Global Fraction of Cell Lines Where Essential: 124/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	3/28
bone	3/26
breast	7/33
central nervous system	9/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	3/20
lung	14/75
lymphocyte	2/16
ovary	5/26
pancreas	7/24
peripheral nervous system	2/16
plasma cell	5/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	0/5

Expression Distribution

endoplasmic reticulum signal peptide binding
signal recognition particle binding
signal recognition particle
signal recognition particle, endoplasmic reticulum targeting
7S RNA binding
ribosome
ribosome binding
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
protein domain specific binding
establishment of protein localization to membrane
protein targeting
focal adhesion
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
nucleolus
intracellular protein transport
endoplasmic reticulum
response to drug
RNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport