SRP19

Entrez Summary: N/A
UniProt Summary: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 121/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	6/28
blood	3/28
bone	4/26
breast	4/33
central nervous system	10/56
cervix	0/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	5/16
kidney	1/21
liver	2/20
lung	14/75
lymphocyte	1/16
ovary	6/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	6/15
prostate	0/1
skin	4/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	3/5

Expression Distribution

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
signal recognition particle
signal recognition particle, endoplasmic reticulum targeting
7S RNA binding
ribosome binding
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
cellular protein-containing complex assembly
nucleolus
intracellular protein transport
response to drug
RNA binding
protein transport
intracellular transport
peptide transport
protein-containing complex assembly
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
protein-containing complex subunit organization