SRP19 [The Human Chemical-Genetic Interaction Map Project]

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======= SRP19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP19
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6728|6728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09132|P09132]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRP19|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|
|signal recognition particle|
|signal recognition particle, endoplasmic reticulum targeting|
|7S RNA binding|
|ribosome binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|nucleolus|
|intracellular protein transport|
|response to drug|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.77|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.78|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srp72|SRP72]]|0.493|
|[[:human genes:m:mars|MARS]]|0.48|
|[[:human genes:s:srp68|SRP68]]|0.457|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.454|
|[[:human genes:g:gtf3a|GTF3A]]|0.45|
|[[:human genes:h:hars|HARS]]|0.437|
|[[:human genes:e:eif4e|EIF4E]]|0.416|
|[[:human genes:r:rtcb|RTCB]]|0.402|
|[[:human genes:t:tbca|TBCA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 121/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|3/28|
|bone|4/26|
|breast|4/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|1/21|
|liver|2/20|
|lung|14/75|
|lymphocyte|1/16|
|ovary|6/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP19 Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>