DHPS
Gene Information
- Official Symbol: DHPS
- Official Name: deoxyhypusine synthase
- Aliases and Previous Symbols: N/A
- Entrez ID: 1725
- UniProt: P49366
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Pfam Domains GO Terms
Pfam Domains
| DS |
GO Terms
| deoxyhypusine synthase activity |
| peptidyl-lysine modification to peptidyl-hypusine |
| spermidine metabolic process |
| polyamine metabolic process |
| cellular biogenic amine metabolic process |
| cellular amine metabolic process |
| amine metabolic process |
| ammonium ion metabolic process |
| protein maturation |
| peptidyl-lysine modification |
| translation |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| peptidyl-amino acid modification |
| positive regulation of cell population proliferation |
| identical protein binding |
| organonitrogen compound biosynthetic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| THG1L | 0.656 |
| RPTOR | 0.615 |
| RTCB | 0.604 |
| HARS | 0.604 |
| RNMT | 0.602 |
| TRIAP1 | 0.587 |
| DOHH | 0.584 |
| ALG1 | 0.57 |
| UAP1 | 0.567 |
| GMPPB | 0.563 |
| DPAGT1 | 0.558 |
| SRP14 | 0.544 |
| SLC25A26 | 0.544 |
| PMM2 | 0.541 |
| ALG13 | 0.537 |
| UHRF1 | 0.536 |
| PELO | 0.534 |
| ATXN10 | 0.525 |
| NAE1 | 0.525 |
| GFPT1 | 0.524 |
| EIF4E | 0.52 |
| HSPD1 | 0.519 |
| GTF3C3 | 0.518 |
| EXOC4 | 0.518 |
| DDX20 | 0.516 |
| PPCS | 0.514 |
| VEZT | 0.513 |
| ADSL | 0.512 |
| MED16 | 0.51 |
| YARS | 0.507 |
| UTP23 | 0.498 |
| OSGEP | 0.498 |
| HCCS | 0.497 |
| GTF3C2 | 0.496 |
| RPE | 0.493 |
| TIMM13 | 0.493 |
| GNB1L | 0.49 |
| MTOR | 0.488 |
| DDOST | 0.487 |
| WDR24 | 0.487 |
| GTF3C4 | 0.483 |
| CASP9 | 0.477 |
| PAM16 | 0.476 |
| HAUS8 | 0.475 |
| GTF3C6 | 0.474 |
| ATP5O | 0.473 |
| ATP5J | 0.473 |
| TBCA | 0.473 |
| EPRS | 0.472 |
| EXOC3 | 0.472 |
| ALG5 | 0.469 |
| TAZ | 0.469 |
| ATP5B | 0.468 |
| TEN1 | 0.468 |
| TTI2 | 0.468 |
| MEAF6 | 0.466 |
| NARS | 0.465 |
| ALG2 | 0.464 |
| RPP21 | 0.462 |
| ENY2 | 0.461 |
| ZRSR2 | 0.461 |
| PPA2 | 0.46 |
| FAF2 | 0.458 |
| WDR59 | 0.456 |
| OIP5 | 0.456 |
| POLR3B | 0.454 |
| BAP1 | 0.452 |
| LAMTOR5 | 0.452 |
| GEMIN6 | 0.452 |
| RPN1 | 0.451 |
| TAMM41 | 0.449 |
| AARS | 0.449 |
| DPF2 | 0.448 |
| SRP68 | 0.447 |
| CBFB | 0.446 |
| PLAA | 0.443 |
| NSMCE1 | 0.442 |
| VRK1 | 0.44 |
| ROMO1 | 0.439 |
| CCDC101 | 0.439 |
| BAK1 | 0.438 |
| CRCP | 0.437 |
| TRNT1 | 0.436 |
| TXNL4B | 0.434 |
| LSM11 | 0.434 |
| CHCHD4 | 0.433 |
| TTC4 | 0.432 |
| ELAC2 | 0.431 |
| TMEM41B | 0.43 |
| SUPV3L1 | 0.429 |
| SNF8 | 0.428 |
| POLR3H | 0.428 |
| TRMT5 | 0.427 |
| FNTA | 0.426 |
| RBM14 | 0.425 |
| EEF1E1 | 0.425 |
| APAF1 | 0.424 |
| TGS1 | 0.424 |
| TSEN54 | 0.424 |
| DR1 | 0.424 |
| THOC6 | 0.422 |
| RABGGTB | 0.422 |
| GTF3A | 0.421 |
| ORAOV1 | 0.417 |
| CRLS1 | 0.417 |
| DAD1 | 0.416 |
| PPP2R3C | 0.416 |
| DDX39A | 0.416 |
| ZNF259 | 0.415 |
| UXT | 0.415 |
| SPCS2 | 0.415 |
| SDHA | 0.415 |
| TRMT10A | 0.414 |
| SPCS3 | 0.414 |
| METAP2 | 0.414 |
| UBE2K | 0.413 |
| EIF3F | 0.413 |
| CHORDC1 | 0.412 |
| WARS | 0.412 |
| VHL | 0.411 |
| CYCS | 0.411 |
| DDX55 | 0.411 |
| ATIC | 0.41 |
| PPP4C | 0.409 |
| DHRSX | 0.409 |
| ORC3 | 0.409 |
| TSEN34 | 0.408 |
| AASDHPPT | 0.407 |
| SLC35B1 | 0.406 |
| CARS | 0.406 |
| TMA16 | 0.406 |
| CCT7 | 0.404 |
| CDIPT | 0.403 |
| TTI1 | 0.402 |
| PAX5 | 0.402 |
| BUB3 | 0.402 |
| GABPA | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 558/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 22/28 |
| blood | 18/28 |
| bone | 15/26 |
| breast | 26/33 |
| central nervous system | 49/56 |
| cervix | 4/4 |
| colorectal | 12/17 |
| esophagus | 12/13 |
| fibroblast | 0/1 |
| gastric | 13/16 |
| kidney | 9/21 |
| liver | 18/20 |
| lung | 60/75 |
| lymphocyte | 11/16 |
| ovary | 17/26 |
| pancreas | 19/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 7/15 |
| prostate | 1/1 |
| skin | 17/24 |
| soft tissue | 5/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 25/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1326
- Expression level (log2 read counts): 5.83
Expression Distribution
DHPS Expression in NALM6 Cells: 5.83