AASDHPPT

Gene Information

Official Symbol: AASDHPPT
Official Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Aliases and Previous Symbols: N/A
Entrez ID: 60496
UniProt: Q9NRN7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RS-1 10μM R08 exp519	-2.61
YM155 0.001μM R08 exp432	-2.06
Nifuroxazide 5μM R03 exp102	-1.88
Prochlorperazine 5.2μM R02 exp77	-1.84
GSK-LSD1 10μM R03 exp123	-1.81
MS094 2μM R03 exp136	-1.81
MKC9989 10μM R03 exp133	-1.8
Isonicotinamide 500μM R03 exp129	-1.72
Tozasertib 0.1μM R07 exp414	1.72
HMS-I1 10μM R06 exp256	1.74
SNS-032 15μM R08 exp443	1.8
Dorsomorphin 5μM R07 exp357	1.81
UM0129480 7μM R02 exp85	1.81
WYE-354 6μM R02 exp90	1.81
TIC10 10μM R08 exp532	1.82
Aphidicolin 0.4μM R08 exp440	1.88
GSK-J4 1.5μM R08 exp441	1.98
Vinblastine 0.2μM R03 exp108	1.99
Atovaquone 15μM R08 exp451	2.22
Tanespimycin 14μM R08 exp527	2.22
BI-D1870 3.15μM R02 exp66	2.39
Genistein 15μM R07 exp360	2.41
Hinokiflavone 12μM R08 exp487	2.45
JQ1 0.8μM R08 exp435	2.61
Hydroxyurea 100μM R07 exp329	3.01
Ammonium tetrathiomolybdate 10μM R08 exp448	3.45

Gene	Correlation
SLC25A26	0.738
NFU1	0.647
TPK1	0.629
IBA57	0.583
GLRX5	0.577
PMM2	0.576
TRIAP1	0.576
BCS1L	0.574
ISCA2	0.573
RPE	0.571
ATIC	0.567
SLC25A19	0.555
THG1L	0.555
ATXN10	0.552
MRPL21	0.545
DPAGT1	0.542
SUPV3L1	0.54
RPIA	0.536
ALG1	0.535
SRP14	0.531
MRPS5	0.53
LSM10	0.53
VEZT	0.528
SUCLA2	0.521
TKT	0.519
GFM2	0.517
C17orf89	0.516
PDSS1	0.516
FH	0.515
C12orf65	0.513
COX16	0.511
MRPL23	0.509
RPUSD4	0.509
CHCHD4	0.505
HSD17B10	0.495
DARS2	0.493
ROMO1	0.493
PPCS	0.492
DNLZ	0.489
ALG13	0.488
MRPS34	0.488
GEMIN8	0.486
MRPS33	0.485
CRLS1	0.482
MRPS2	0.481
TMEM242	0.481
RFK	0.48
ENO1	0.478
UQCRC2	0.477
FDXR	0.475
LONP1	0.475
YARS2	0.471
TUFM	0.47
MRPS18A	0.47
DOHH	0.467
MRPS16	0.467
SARS2	0.464
GEMIN6	0.464
RBFA	0.463
MRP63	0.463
GTPBP10	0.463
MRPL15	0.463
NDUFA3	0.462
GEMIN7	0.461
SCO2	0.461
MRPS14	0.461
TAZ	0.46
UHRF1	0.459
MRPL27	0.459
DAP3	0.458
COQ5	0.455
RBMX2	0.454
GFM1	0.452
WBSCR16	0.451
NDUFB5	0.45
ABHD11	0.45
MRPS26	0.449
MRPL47	0.449
HAUS8	0.449
TPI1	0.449
PGM3	0.447
TRMT61A	0.446
DHRSX	0.444
ZRSR2	0.444
ADSL	0.444
FARS2	0.444
MRPL53	0.443
SRD5A3	0.443
KCTD5	0.441
MRPS36	0.438
COQ2	0.438
HCCS	0.437
N6AMT1	0.437
KIAA0391	0.436
TAMM41	0.436
NDUFB3	0.434
PPP6C	0.434
MTPAP	0.432
MRPS21	0.43
PGP	0.43
EARS2	0.43
MRPS6	0.429
RFT1	0.429
TRMT5	0.429
PGK1	0.428
RNASEH1	0.427
NDUFB6	0.427
UTP23	0.426
ZCRB1	0.426
MCAT	0.426
NDUFB11	0.425
PPA2	0.424
GMPPB	0.423
NBN	0.423
DHX30	0.422
FASTKD5	0.422
UBA3	0.42
MRPS11	0.419
MIPEP	0.419
ATP5SL	0.419
GFPT1	0.417
C15orf41	0.417
CEP57	0.416
UAP1	0.415
TRMT10A	0.415
SOD2	0.415
COX6C	0.414
CBX3	0.414
ELAC2	0.413
TBCA	0.413
MRPS23	0.413
MRPS9	0.412
LIPT2	0.412
COQ3	0.411
HARS	0.411
PPCDC	0.411
RTCB	0.411
UQCR10	0.408
DHPS	0.407
MED16	0.407
MRPL36	0.407
NDUFAF4	0.406
TRNT1	0.405
DR1	0.404
TEN1	0.403
POLG	0.403
MTRF1L	0.403
COX17	0.402
GATC	0.401
SELRC1	0.401
PDK3	0.401
MRPL20	0.4

Global Fraction of Cell Lines Where Essential: 17/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	4/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1389
Expression level (log2 read counts): 5.14

Expression Distribution

holo-[acyl-carrier-protein] synthase activity
lysine biosynthetic process
lysine biosynthetic process via aminoadipic acid
pantothenate metabolic process
lysine metabolic process
aspartate family amino acid biosynthetic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
water-soluble vitamin metabolic process
vitamin metabolic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
magnesium ion binding
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
cofactor metabolic process
monocarboxylic acid metabolic process
small molecule biosynthetic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process